DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4927 and Hgfac

DIOPT Version :9

Sequence 1:	NP_001033953.1	Gene:	CG4927 / 36852	FlyBaseID:	FBgn0034139	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	XP_006504094.1	Gene:	Hgfac / 54426	MGIID:	1859281	Length:	658	Species:	Mus musculus

Alignment Length:	408	Identity:	106/408 - (25%)
Similarity:	172/408 - (42%)	Gaps:	101/408 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CSIL-SEFCDNGTG-ECKELSAT-----DCPS-----IFFNLHL--IRNFV-------KYC---D 55
            |:|: :|.|..|.| |.:.:::|     .|.:     ::..||:  :...|       .||   |
Mouse   275 CNIVPTEHCFLGNGTEYRGVASTAASGLSCLAWNSDLLYQELHVDSVAAAVLLGLGPHAYCRNPD 339

  Fly    56 KSNHIVCCLLPNN-MQPQSQQFSANIGLRRFEKE------------------CRRFNEIRTSCRT 101
            |.....|.::.:| :..:..:.:|...|.|...:                  |.:.::.||..|
Mouse   340 KDERPWCYVVKDNALSWEYCRLTACESLARVHSQTPEILAALPESAPAVRPTCGKRHKKRTFLR- 403

  Fly   102 TPFIVGGAKAAGREFPFMA--LLGQRGKNSSQIDWDCGAIIIHPKFVLTAAHCLETSETKEQRLD 164
             |.|:||:.:.....|::|  .:|    ||.     |...::|..:|::||||...|..::
Mouse   404 -PRIIGGSSSLPGSHPWLAAIYIG----NSF-----CAGSLVHTCWVVSAAHCFANSPPRD---- 454

  Fly   165 PNYDGPKYVVRLGELDYNSTTDDAQPQDFRVLNYVVHPAYGEDDDTGSRKNDIAVVELEME---- 225
                  ...|.||:..:|.|||  ..|.|.:..||.:..|..   .....:|:.::.|:.:
Mouse   455 ------SITVVLGQHFFNRTTD--VTQTFGIEKYVPYTLYSV---FNPNNHDLVLIRLKKKGERC 508

  Fly   226 ATFSEYVAPACLPLDGGN----EQLQVAAAGWG-------ATSESGHASSHLLKVSLDRYDVAEC 279
            |..|::|.|.|||..|.:    .:.|:  ||||       :|..|.:::| ||:..:......:|
Mouse   509 AVRSQFVQPICLPEAGSSFPTGHKCQI--AGWGHMDEMQSSTDVSSYSNS-LLEALVPLVADHKC 570

  Fly   280 SQRLEHKIDVR-TQLCAGSRSTSADTCYGDSGGPVFVQHPIYSCLKQ----VIGITSYGLVCGVQ 339
            |....:..|:. ..||||.....:|.|.||||||:.       |.|.    :.||.|:|..||..
Mouse   571 SSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLV-------CEKNGVAYLYGIISWGDGCGRL 628

  Fly   340 GLPSVYTKVHLYTDWIEN 357
            ..|.|||:|..|.|||.:
Mouse   629 NKPGVYTRVANYVDWIND 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4927	NP_001033953.1	Tryp_SPc	105..358	CDD:238113	80/275 (29%)
CG4927	NP_001033953.1	Tryp_SPc	105..355	CDD:214473	78/271 (29%)
Hgfac	XP_006504094.1	FN2	99..145	CDD:128373
		EGF_CA	159..194	CDD:238011
		FN1	197..237	CDD:238018
		EGF_CA	242..275	CDD:238011	106/408 (26%)
		Kringle	283..364	CDD:333799	15/80 (19%)
		Tryp_SPc	406..646	CDD:238113	80/273 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050