DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4927 and Prss12

DIOPT Version :9

Sequence 1:	NP_001033953.1	Gene:	CG4927 / 36852	FlyBaseID:	FBgn0034139	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_032965.1	Gene:	Prss12 / 19142	MGIID:	1100881	Length:	761	Species:	Mus musculus

Alignment Length:	389	Identity:	109/389 - (28%)
Similarity:	162/389 - (41%)	Gaps:	93/389 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AVICSILS----------EFCDNGTG-------EC--KELSATDCPSIFFNLHLIRNFVKYCDKS 57
            ||||..|.          .:...|.|       :|  .|.:..||.......|..|:     .:.
Mouse   421 AVICRQLGYKGPARARTMAYFGEGKGPIHMDNVKCTGNEKALADCVKQDIGRHNCRH-----SED 480

  Fly    58 NHIVCCLLPN--NMQPQSQQFSANIGLRRFEKECRRFNEIRTSCRTTPFIVGGAKAAGREFPFMA 120
            ..::|..|..  :.....:..|:..|||...:..:|             |:||..:....:|:.|
Mouse   481 AGVICDYLEKKASSSGNKEMLSSGCGLRLLHRRQKR-------------IIGGNNSLRGAWPWQA 532

  Fly   121 LLGQRGKNSSQIDWD----CGAIIIHPKFVLTAAHCLETSETKEQRLDPNYDGPKYVVRLGELDY 181
            .|..|..:.     |    |||.::...:|||||||.:......:         .|.||:|  ||
Mouse   533 SLRLRSAHG-----DGRLLCGATLLSSCWVLTAAHCFKRYGNNSR---------SYAVRVG--DY 581

  Fly   182 NSTTDDAQPQDFRVLNYVVHPAYGEDDDTGSRKN-DIAVVEL----EMEATFSEYVAPACLPLDG 241
            ::...:...|:..|...|:|..|..|     |.: |||:|.|    |..|..|.:|.||||||
Mouse   582 HTLVPEEFEQEIGVQQIVIHRNYRPD-----RSDYDIALVRLQGPGEQCARLSTHVLPACLPL-- 639

  Fly   242 GNEQLQVAAA-----GWGATSESGHASSHLLKVSL-----DRYDVAECSQRLEHKIDVRTQLCAG 296
            ..|:.|..|:     |||   ::|.|.|..|:.:.     .|:    |.:|.:.....| .||||
Mouse   640 WRERPQKTASNCHITGWG---DTGRAYSRTLQQAAVPLLPKRF----CKERYKGLFTGR-MLCAG 696

  Fly   297 S--RSTSADTCYGDSGGPVFVQHPIYSCLKQVIGITSYGLVCGVQGLPSVYTKVHLYTDWIENI 358
            :  .....|:|.||||||:..:.|..|.:  |.|:||:|..|||:..|.|||:|..:..||:::
Mouse   697 NLQEDNRVDSCQGDSGGPLMCEKPDESWV--VYGVTSWGYGCGVKDTPGVYTRVPAFVPWIKSV 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4927	NP_001033953.1	Tryp_SPc	105..358	CDD:238113	89/273 (33%)
CG4927	NP_001033953.1	Tryp_SPc	105..355	CDD:214473	87/270 (32%)
Prss12	NP_032965.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..87
		KR	83..159	CDD:214527
		SR	166..265	CDD:214555
		SRCR	171..265	CDD:278931
		SR	273..372	CDD:214555
		SRCR	278..371	CDD:278931
		SR	386..485	CDD:214555	13/68 (19%)
		SRCR	396..485	CDD:278931	13/68 (19%)
		Zymogen activation region	505..516		3/10 (30%)
		Tryp_SPc	516..755	CDD:214473	88/284 (31%)
		Tryp_SPc	517..758	CDD:238113	89/273 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960