DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4927 and Plau

DIOPT Version :9

Sequence 1:	NP_001033953.1	Gene:	CG4927 / 36852	FlyBaseID:	FBgn0034139	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_032899.1	Gene:	Plau / 18792	MGIID:	97611	Length:	433	Species:	Mus musculus

Alignment Length:	405	Identity:	110/405 - (27%)
Similarity:	164/405 - (40%)	Gaps:	97/405 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CSI-LSEFCDNGTGEC-----------KELSATDCPSIF---FNLHLIRNFVKYCDKSNHIVCCL 64
            |.| .|:.|.:|.|:.           :...|.:.|::.   :|.|..........|.|:   |.
Mouse    63 CEIDASKTCYHGNGDSYRGKANTDTKGRPCLAWNAPAVLQKPYNAHRPDAISLGLGKHNY---CR 124

  Fly    65 LPNNMQPQSQQFS-ANIGLRRFEKEC-----------------RRFNEIRTSCRTTPFIVGGAKA 111
            .|:|   |.:.:. ..||||:|.:||                 :.|...:.:.|....||||...
Mouse   125 NPDN---QKRPWCYVQIGLRQFVQECMVHDCSLSKKPSSSVDQQGFQCGQKALRPRFKIVGGEFT 186

  Fly   112 AGREFPFMALLGQRGKNSSQIDWDCGAIIIHPKFVLTAAHCLETSETKEQRLDPNYDGPKYVVRL 176
            .....|:.|.:.|:.|..|...:.||..:|.|.:|.:||||......||          .|||.|
Mouse   187 EVENQPWFAAIYQKNKGGSPPSFKCGGSLISPCWVASAAHCFIQLPKKE----------NYVVYL 241

  Fly   177 G---ELDYNSTTDDAQPQD--FRVLNYVVHPAYGEDDDTGSRKNDIAVVELEME----ATFSEYV 232
            |   |..||       |.:  |.|...::|..|.|  |:.:..||||::::...    |..|..:
Mouse   242 GQSKESSYN-------PGEMKFEVEQLILHEYYRE--DSLAYHNDIALLKIRTSTGQCAQPSRSI 297

  Fly   233 APACLP---LDG--GNEQLQVAAAGWGATSESGHASSHLLKVSLDR-YDVAECSQ------RLEH 285
            ...|||   .|.  |::   ....|:|..|||.:.....||:|:.: ....:|.|      .:.:
Mouse   298 QTICLPPRFTDAPFGSD---CEITGFGKESESDYLYPKNLKMSVVKLVSHEQCMQPHYYGSEINY 359

  Fly   286 KIDVRTQLCAGSRSTSADTCYGDSGGPVFVQ---HPIYSCLKQVIGITSYGLVCGVQGLPSVYTK 347
            |:     |||.......|:|.||||||:...   .|..|      ||.|:|..|..:..|.|||:
Mouse   360 KM-----LCAADPEWKTDSCKGDSGGPLICNIEGRPTLS------GIVSWGRGCAEKNKPGVYTR 413

  Fly   348 VHLYTDWIENIVWGE 362
            |..:.|||::.: ||
Mouse   414 VSHFLDWIQSHI-GE 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4927	NP_001033953.1	Tryp_SPc	105..358	CDD:238113	83/276 (30%)
CG4927	NP_001033953.1	Tryp_SPc	105..355	CDD:214473	81/273 (30%)
Plau	NP_032899.1	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	35..58
		Kringle	71..152	CDD:333799	20/86 (23%)
		Connecting peptide	153..179		2/25 (8%)
		Tryp_SPc	180..424	CDD:238113	83/276 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050