DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4927 and tmprss2.15

DIOPT Version :9

Sequence 1:	NP_001033953.1	Gene:	CG4927 / 36852	FlyBaseID:	FBgn0034139	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	XP_031752206.1	Gene:	tmprss2.15 / 101732233	XenbaseID:	XB-GENE-22065943	Length:	504	Species:	Xenopus tropicalis

Alignment Length:	392	Identity:	101/392 - (25%)
Similarity:	158/392 - (40%)	Gaps:	82/392 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ICSILSEFCD------NGTGE--CKEL-------------SATDCPSIFFNLHLIRNFVKYCDKS 57
            :|.:.|::||      |||.|  |..|             .||..|..         :.::.|.|
Frog   136 VCVLYSQWCDGIPQCPNGTDEQTCVRLYGPNFQLQAYSPAKATWLPVC---------YDEWSDNS 191

  Fly    58 NHIVCCLLPNNMQP--QSQQF------------SANIGLR-----RFEKECRRFNEIRTSC---- 99
            ..|.|..:..:|..  ||.|.            |:|:..:     .:...|...|.:...|
Frog   192 GKIACQDIGYSMSSYYQSSQLLASSSNGYFVLQSSNVTGKMYTNLNYSATCASGNMVSLRCISCG 256

  Fly   100 ---RTTPFIVGGAKAAGREFPFMALLGQRGKNSSQIDWDCGAIIIHPKFVLTAAHCLETSETKEQ 161
               :....||||..|:..::|:...|.:....|..:   ||..||.|.:::|||||:..|.:...
Frog   257 LSTKVDSRIVGGTPASVGDWPWQVELLKLVGTSIYL---CGGSIITPHWIVTAAHCVYGSTSTPS 318

  Fly   162 RLDPNYDGPKYVVRLGELDYNSTTDDAQPQDFRVLNYVVHPAYGEDDDTGSRKNDIAVVELEMEA 226
                     .:.|..|.|    |........:.|...:|||:|    .:.::..|:|:::|....
Frog   319 ---------AFKVFAGSL----TIQSYYSAGYTVERALVHPSY----SSYTQIYDVALLKLTAAL 366

  Fly   227 TFSEYVAPACLPLDG--GNEQLQVAAAGWGATSESGHASSHLLKVSLDRYDVAECSQRLEHKIDV 289
            .|:..:.|.|||..|  ..|......:|||.|:|.|..|.:|:..|:.......|:|...:...:
Frog   367 VFTTNLRPVCLPNVGMPWAEGQPCWISGWGTTAEGGSISKNLMAASVPIISSTTCNQAAVYGGAI 431

  Fly   290 -RTQLCAGSRSTSADTCYGDSGGPVFVQHPIYSCLKQVIGITSYGLVCGVQGLPSVYTKVHLYTD 353
             .|.:|||..|...|||.||||||:..:   .:.|..::|.||:|..|.....|.||..|.::.:
Frog   432 SSTMMCAGYLSGGTDTCQGDSGGPLVTK---TNSLWWLVGDTSWGYGCARAYKPGVYGNVTVFIE 493

  Fly   354 WI 355
            ||
Frog   494 WI 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4927	NP_001033953.1	Tryp_SPc	105..358	CDD:238113	75/254 (30%)
CG4927	NP_001033953.1	Tryp_SPc	105..355	CDD:214473	73/252 (29%)
tmprss2.15	XP_031752206.1	LDLa	93..121	CDD:238060
		SRCR_2	164..259	CDD:406055	16/103 (16%)
		Tryp_SPc	265..498	CDD:238113	75/254 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910