DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4945 and sbk1

DIOPT Version :9

Sequence 1:	NP_788382.1	Gene:	CG4945 / 36850	FlyBaseID:	FBgn0034137	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	XP_688256.4	Gene:	sbk1 / 559792	ZFINID:	ZDB-GENE-091118-114	Length:	400	Species:	Danio rerio

Alignment Length:	376	Identity:	116/376 - (30%)
Similarity:	179/376 - (47%)	Gaps:	21/376 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKKPRGNIHKIREFELEKIQLVDEFDIIQIVGEGWFGKILLVEHRGSQTEMVLKAVPKPYVTLR 65
            |...|..::..:....|...::..:|::|..:|:|.:||:.||.||...|::.||.|.|....||
Zfish    28 MGGAPVEDMQALSITSLSASEVEQQFELISPLGKGTYGKVDLVVHRTQGTKLALKYVSKNKTKLR 92

  Fly    66 DFYREFHYGLHLGVHRHIVTTYDVAFETAGFYVFTQEYAPLGDLTSNV-TDSGVGEVYSKRVAKQ 129
            .|.||:.....||....|:...:|.|||...|||.|||||.|||...: ..:|:.|...||..:|
Zfish    93 SFLREYSLNAALGCSPFIIKVLNVLFETEDSYVFGQEYAPAGDLFDIIPPQAGLPEEMVKRCVQQ 157

  Fly   130 LASAIDYMHSKDIVHRDIKLDNVLIYRSDFQRIKLCDFGESFPTGSTVERRNEWLPYSPPEVLEI 194
            |..|:|:||||.:||||:|.:|||::..:.:|:||.|.|.:..:||.::|.:..:||:..||.:.
Zfish   158 LGLALDFMHSKSLVHRDVKPENVLLFDRECRRVKLADLGMTRRSGSRIKRISGTIPYTAAEVCQA 222

  Fly   195 KPEGSYKADPSHDVWQFGIVIFVCLTGCLPWQKAASDDPRYVRYLAWQGGLMMMPLRRTPRLFKL 259
            ..........:.|||.||:::|..|||..||:.|..:|..:..:..||.|  ..|....|..::.
Zfish   223 SVSEGIIVATTQDVWAFGVLLFCMLTGNFPWEAALPNDAFFAEFQRWQRG--AFPPGSVPSQWRR 285

  Fly   260 LTSNAQRMFKRFFARISNRPKSLADVTKFLDDRWLAKTAQKEMAEYETDELCPSMYSFHSSPDEK 324
            .:.:|.|||.|..|....|...:.:|..||  ::......:..|...|.....:..|.|...|..
Zfish   286 FSDDALRMFGRLLALEPERRCGVKEVFYFL--KYDLLNHHRRRASCRTSRGGATHCSAHRHADPS 348

  Fly   325 NKLLYTLADCGIETNVDRQQKKNRIKDWIESSIITEEDEEENEETNSASPS 375
            ..   :...|...|.:.|             ||::|......|.:.|.||:
Zfish   349 PP---SGTSCLRPTPLKR-------------SILSELHSSREESSKSPSPN 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4945	NP_788382.1	SPS1	25..358	CDD:223589	107/333 (32%)
CG4945	NP_788382.1	STKc_SBK1	32..293	CDD:270889	96/261 (37%)
sbk1	XP_688256.4	S_TKc	53..322	CDD:214567	98/272 (36%)
sbk1	XP_688256.4	STKc_SBK1	59..319	CDD:270889	96/263 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590133
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1345
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3917
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1221624at2759
OrthoFinder	1	1.000	-	-		FOG0002130
OrthoInspector	1	1.000	-	-		mtm6333
orthoMCL	1	0.900	-	-		OOG6_106722
Panther	1	1.100	-	-	LDO	PTHR24359
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4887
SonicParanoid	1	1.000	-	-		X768
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.790