DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and Slc6a2

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_112633.2	Gene:	Slc6a2 / 83511	RGDID:	621822	Length:	617	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	330/588 - (56%)
Similarity:	421/588 - (71%)	Gaps:	35/588 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLF 81
            |.|    :..||||..|:||||||:|||||||||||||||||||||||||:||.:.|::.|:|||
  Rat    50 DGD----AQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLF 110

  Fly    82 YMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWT 146
            ||||||||.||:||.|.| ::.|.|||:||||:|||.||.|||||||||||.:.|||||.:||||
  Rat   111 YMELALGQFNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWT 174

  Fly   147 SCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSA 211
            :|.:.||:|||...:..|||   |:|:::. |:.      |..|                    .
  Rat   175 NCGHAWNSPNCTDPKLLNAS---VLGDHTK-YSK------YKFT--------------------P 209

  Fly   212 ASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVL 276
            |:|::.|.:|.|:.|.||||:|..:|.:.|||::|.::.|||||||:.|||||||.||..||.||
  Rat   210 AAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVL 274

  Fly   277 LILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNV 341
            .:||:.|:||||:..||..||..:|..:.:|.||:|||||:|||||.|||||:|:|||||:.||.
  Rat   275 FVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNC 339

  Fly   342 YKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFW 406
            |:||||||.||..||||:||.|||:||||||...|:||||||||.|||||:||.||:|:..||||
  Rat   340 YRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFW 404

  Fly   407 ALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFF 471
            |::||:|||.||||||.||.||:||.|:|:|..:||:|:||...:....|::.:...|:||.|..
  Rat   405 AVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVL 469

  Fly   472 HLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITV 536
            .|||.:|||.|||.||..|||.|||.||.:|||.||:.|:||.||.||::||:||:|.||||:.|
  Rat   470 TLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVV 534

  Fly   537 YGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQQ 601
            ..:|.::||||.|||||.|||.:||.||.||::::||..|:|..|..|||.:|.....||..:..
  Rat   535 VSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHH 599

  Fly   602 SMA 604
            .:|
  Rat   600 LVA 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	326/569 (57%)
Slc6a2	NP_112633.2	SLC5-6-like_sbd	56..615	CDD:382020	328/578 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	664	1.000	Domainoid score	I144
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H816
Inparanoid	1	1.050	675	1.000	Inparanoid score	I694
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	1	1.000	-	-		otm45897
orthoMCL	1	0.900	-	-		OOG6_101590
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840