DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and slc6a3

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_571830.1	Gene:	slc6a3 / 80787	ZFINID:	ZDB-GENE-010316-1	Length:	629	Species:	Danio rerio

Alignment Length:	615	Identity:	313/615 - (50%)
Similarity:	413/615 - (67%)	Gaps:	47/615 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SPTGHISKSKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFL 66
            :|..|   |.|.| |.:.:.| ..:||||..|:||||||||||||||||||||||||||||||||
Zfish    56 NPGAH---SHTHT-HTHTHPS-GQQRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFL 115

  Fly    67 VPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWS 131
            |||.:.:|:.|:|||||||||||:||:||...| ::.|:|||:|:.|:||:.||..||||||||:
Zfish   116 VPYLLFMVIAGMPLFYMELALGQYNREGAAGVW-KICPIFKGVGFTVILISLYVGSYYNVIIAWA 179

  Fly   132 LRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSS 196
            |.:.|:||:..|||..|||.||:|||   ...||:                   |.|:||..
Zfish   180 LFYLFSSFSGELPWIHCNNTWNSPNC---SDPNAT-------------------LLNDTYKT--- 219

  Fly   197 LDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTS 261
                         :.|.|||.|.:|.::.|.||.||||.:|.:..||.:|.::.|||||||:.||
Zfish   220 -------------TPALEYFERGVLHVHESSGIDDLGAPRWQLTACLAVVIVVLYFSLWKGVKTS 271

  Fly   262 GKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFG 326
            |||||.||..||.||.:||:||:||||:..||:.||:.:|..:|.|:||::||||:.||||.|||
Zfish   272 GKVVWITATMPYVVLTVLLLRGVTLPGAIDGIKAYLSVDFLRLYDAQVWIEAATQICFSLGVGFG 336

  Fly   327 VLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFV 391
            ||:|::||||:.||.|:||::||.|||.|||.:||||||.||||:....|.::.|||:||||||:
Zfish   337 VLIAFSSYNKFSNNCYRDAIITSSINSLTSFFSGFVIFSFLGYMSQKHNVALDKVATDGPGLVFI 401

  Fly   392 VYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYF 456
            :||.||||:|.|:.||:|||:||||||:||:.||.|::||.|.|||..:.::||||...:....|
Zfish   402 IYPEAIATLPGSSVWAVIFFIMLLTLGIDSAMGGMESVITGLIDEFKFLHKHRELFTLFIVVSTF 466

  Fly   457 VVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQV 521
            ::.|...|.||.|.|.|||.:|||.|||..|..|||.::|.||.:|||:||.:|||..||.||::
Zfish   467 LISLICVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGIAWFYGVDRFSDDIEEMIGQRPGLYWRL 531

  Fly   522 CWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSL 586
            ||:||:|.||||:.|.....:.|..|..|.:|:||..:|||::.||::|:|..|.:|..|.|||.
Zfish   532 CWKFVSPCFLLFMVVVSFATFNPPKYGSYYFPTWATMVGWCLSISSMIMVPLYAFYKFCSLPGSF 596

  Fly   587 RQRFTILTTPWRDQQSMAMVLNGVTTEVTV 616
            ..:.....||..|..   :|..|...:.|:
Zfish   597 CDKLAYAITPETDHH---LVERGEVRQFTL 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	301/569 (53%)
slc6a3	NP_571830.1	SLC6sbd_DAT1	76..623	CDD:212083	305/588 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	637	1.000	Domainoid score	I160
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	651	1.000	Inparanoid score	I773
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	1	1.000	-	-		otm25764
orthoMCL	1	0.900	-	-		OOG6_101590
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840