Protein Alignment DAT and Slc6a21

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_006541333.1
• Gene: Slc6a21 / 76713
• MGIID: 1923963
• Length: 749
• Species: Mus musculus
• Alignment Length: 662
• Identity: 172/662 - (25%)
• Similarity: 275/662 - (41%)
• Gaps: 150/662 - (22%)

  Fly    33 KVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAIT 97
            |.:.:|.::.|::.|.:.|||||||::||||:||:.|.|:|::.||||.|||:.:||..|...|.
Mouse    54 KTENILILVAFSIGLGSTWRFPYLCHQNGGGSFLLMYFILLLLLGIPLMYMEMVIGQWLRMDNIQ 118

  Fly    98 CWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFES 162
            .|..|||...|:||:.:|....|..|.:.:::|||.:...||...|||.:|
Mouse   119 AWKYLVPWLSGVGYSNILACVLVVLYNSALVSWSLFYLGQSFDYPLPWQNC-------------- 169

  Fly   163 QNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRS- 226
                  |::.|.|  ...|| :.|::|.:                      :||..:.| |..|
Mouse   170 ------PLVENLS--MVAGN-TCLWSEPH----------------------QYFWYHTL-LQASN 202

  Fly   227 ---EGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPG 288
               |||.   .:..::.|||...::..|.::...|..|..::.|:.||...:||...||.|.|.|
Mouse   203 QMEEGIE---VLVLNVTLCLFATWIFLYVTMVTRIKISVLMMIFSILFSNVLLLCFFIRTLFLNG 264

  Fly   289 SFLGIQYYL-TPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFIN 352
            |.....:.| |...|.:...:.|..|...|.:|||.|.|.::.:::|.....|..|.|...:.:|
Mouse   265 SVRASLWRLVTIELSILSSLDAWRQAGGHVLYSLGLGMGTIITFSTYQPRGENYIKWASFVAMVN 329

  Fly   353 SATSFIAGFVIFSVLGYMAHTLGVR---------------------------------IEDVA-- 382
            .|||.::.||||.|:|:...|.|..                                 :|.:|
Mouse   330 LATSLLSSFVIFLVMGFWTTTSGTMCIKRSVSNLINLIANGVLPKAAWPPGDIIHKPPLEYLAWI 394

  Fly   383 ---------------------------TEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLD 420
                                       .|||||.:|.:..||:..|.|:|||:||||.|..:||.
Mouse   395 NQLPNNLKSQVIHQTLPCSILIQKEKIMEGPGLSYVAFSQAISLFPGSSFWAIIFFMSLAIMGLG 459

  Fly   421 SSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILV 485
            :.....|.|:..|........::..|....:....|:..|...::.|.|...|.|.......:::
Mouse   460 TMLTLLEGIVLPLQKSISTFAKHPNLVQVLVCLGGFLGSLVFSSRPGSYVVFLFDDLLVPMVLII 524

  Fly   486 AVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVA-PIFLLFITVYGL-IGYEPLTYA 548
            .|..:.::::|:||..||..::...:|......:...|.:|. |..|:.:|:|.| :.|....|
Mouse   525 IVVIQNLSLAWLYGIKRFRAEVFGQLGSLVWSPFTFLWSYVTLPTLLVLLTIYFLNLYYSGSPY- 588

  Fly   549 DYVYPSWANA-------------LGWCIAGSSVVMIPAVA-------------IFKLLSTPGSLR 587
               |.||.::             |||....|.:.::|.:.             |.:.|..|.|.:
Mouse   589 ---YVSWNDSMSHEVKQPYKKIPLGWVTFLSVLALLPILVYPLQHWWYLDDPNICETLEKPLSSK 650

  Fly   588 QRFTI--LTTPW 597
            :..|:  ..|.|
Mouse   651 KTVTVPNRVTQW 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	171/660 (26%)
Slc6a21	XP_006541333.1	SLC5-6-like_sbd	48..622	CDD:382020	164/620 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920