Protein Alignment DAT and Slc6a19

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_083154.1
• Gene: Slc6a19 / 74338
• MGIID: 1921588
• Length: 634
• Species: Mus musculus
• Alignment Length: 634
• Identity: 214/634 - (33%)
• Similarity: 306/634 - (48%)
• Gaps: 139/634 - (21%)

  Fly    27 RETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHN 91
            |..|..|..::|:.:||.|.|.|||||||||..:|||||::|:.|:||..||||.|:|.|:||..
Mouse    32 RPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVFEGIPLLYLEFAIGQRL 96

  Fly    92 RKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPN 156
            |||::..|..:.|..||||.|.:.::|.|..|||.||||.:.:||.||...|||:.|
Mouse    97 RKGSMGVWSSIHPALKGIGIASMFVSFMVGLYYNTIIAWVMWYFFNSFQEPLPWSEC-------- 153

  Fly   157 CRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYIL 221
                        |:           ||    |:|            |:||....::|..:..|..
Mouse   154 ------------PL-----------NQ----NQT------------GYVEECAKSSSVDYFWYRE 179

  Fly   222 ELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTL 286
            .||.|..|.|.|:|:|.:.|||...:.:.|..:.:||.|:||.|:.|:..||.||.|.|||||||
Mouse   180 TLNISTSISDSGSIQWWILLCLTCAWSVLYVCIIRGIETTGKAVYITSTLPYVVLTIFLIRGLTL 244

  Fly   287 PGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFI 351
            .|:..||.:..|||.:.:.....|:||..|||:|....||.|::::|||..|||...|:::.|.|
Mouse   245 KGATNGIVFLFTPNITELSNPNTWLDAGAQVFYSFSLAFGGLISFSSYNSVHNNCEMDSVIVSVI 309

  Fly   352 NSATSFIAGFVIFSVLGYMAHTLGVRIEDV----------------------------------- 381
            |..||..|..|::|::|:.|..   |.:|.
Mouse   310 NGFTSVYAATVVYSIIGFRATE---RFDDCVNTNILTLINGFDLPEGNVTSENFEAYQQWCNATN 371

  Fly   382 --------------------ATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGS 426
                                ..||.||.|:|:..||..||.|..|:::||:||..|||.|.||..
Mouse   372 PQAYAQLKFQTCDINSFLSEGVEGTGLAFIVFTEAITKMPVSPLWSVLFFIMLFCLGLSSMFGNM 436

  Fly   427 EAIITALSD------EFPKIKRNRELFVA----GLFSLYFVVGLASCTQGGFYFFHLLDRYAAGY 481
            |.::..|.|      ::||     ||...    |.:.:.|:..|.|    |.|:..|||.:|...
Mouse   437 EGVVVPLQDLNITPKKWPK-----ELLTGLICLGTYLIAFIFTLNS----GQYWLSLLDSFAGSI 492

  Fly   482 SILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLI------ 540
            .:|:..|.|..||.::||.:||::||..|||..|..:|||.||.|:|:.:|.|.::..:
Mouse   493 PLLIIAFCEMFAVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLIMLVIFLFFFVIEVNKT 557

  Fly   541 --------GYEPLTYADYV-YPSWANALGWCIAGSSVVMIPAVAIFKLL 580
                    .||....:..: ||:|..|:...:||...:.||..||:|.:
Mouse   558 LMYSIWDPNYEEFPKSQKIPYPNWVYAVVVTVAGVPCLSIPCFAIYKFI 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	214/634 (34%)
Slc6a19	NP_083154.1	SLC5-6-like_sbd	32..612	CDD:294310	214/634 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810