Protein Alignment DAT and slc6a4a

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001035061.1
• Gene: slc6a4a / 664719
• ZFINID: ZDB-GENE-060314-1
• Length: 646
• Species: Danio rerio
• Alignment Length: 595
• Identity: 297/595 - (49%)
• Similarity: 400/595 - (67%)
• Gaps: 55/595 - (9%)

  Fly    22 SISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELA 86
            |:...|||||.|:||||||||:||||.|||||||:||:|||||||:||.:|.|.||:||||||||
Zfish    86 SLDPPRETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYLLMAVFGGVPLFYMELA 150

  Fly    87 LGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNI 151
            |||.:|.|.|:.|..:.|:|||||:|:.:||.|:.||||.|:||:|.:..:||..:||||:|||.
Zfish   151 LGQFHRSGCISIWKHVCPIFKGIGFAICIIALYIAFYYNTIMAWALYYLLSSFRATLPWTTCNNR 215

  Fly   152 WNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYF 216
            ||||||..:.|            :||          |.::.|.|.             |.|.|::
Zfish   216 WNTPNCTHYLS------------TDL----------NVSWTNNSI-------------SPAEEFY 245

  Fly   217 NRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLI 281
            .|.:|:::.|.|:|.||.:.|.:|||||.::.:.|||:|||:.|||||||.||.|||.|||||||
Zfish   246 VRQVLQVHLSPGLHQLGWVSWQLALCLLFIFTVVYFSIWKGVKTSGKVVWVTATFPYLVLLILLI 310

  Fly   282 RGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDAL 346
            ||.||||::.|:.:||.|::..:....||:|||.|:|||||||||||||:||||.:|||.|||||
Zfish   311 RGATLPGAWRGVVFYLKPDWKKLLTTTVWLDAAAQIFFSLGPGFGVLLAFASYNPFHNNCYKDAL 375

  Fly   347 LTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATE-GPGLVFVVYPAAIATMPASTFWALIF 410
            :||.:|..|||::|||||:||||||......:|.||.: ||.|:|::|..|||.|||:||:|:||
Zfish   376 ITSSVNCLTSFLSGFVIFTVLGYMAEMRQQGVETVAKDAGPSLLFIIYAEAIANMPAATFFAIIF 440

  Fly   411 FMMLLTLGLDSSFGGSEAIITALSDEFPK-IKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLL 474
            |:|::.|||||:|.|.|.:|||:.||||. :.|.||.||.||..:.::..|::.|.||.:...|.
Zfish   441 FLMIIMLGLDSTFAGLEGVITAMLDEFPHLLARRREWFVLGLVCVCYLGALSTLTYGGAFVVKLF 505

  Fly   475 DRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGL 539
            :.||.|.:::..||.|.|||||.|||.||..|::.|:||.||.:|:|||..:.|.|||||.| ..
Zfish   506 EEYATGPAVITVVFLEVIAVSWFYGTTRFCNDVQLMLGFAPGLFWRVCWIAICPCFLLFIIV-SF 569

  Fly   540 IGYEP-LTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQQSM 603
            :.:.| :...||:||.|...||:||..||.:.:|:..::.|::|.|:.:||
Zfish   570 LAFPPEVKLFDYLYPFWTTVLGYCIGVSSFICVPSYMVYHLVTTKGTFQQR-------------- 620

  Fly   604 AMVLNGVTTE 613
              :|.|:|.|
Zfish   621 --LLKGITPE 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	292/572 (51%)
slc6a4a	NP_001035061.1	SLC5-6-like_sbd	91..628	CDD:444915	295/588 (50%)