Protein Alignment DAT and Slc6a19

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001034811.2
• Gene: Slc6a19 / 664630
• RGDID: 1594328
• Length: 634
• Species: Rattus norvegicus
• Alignment Length: 656
• Identity: 224/656 - (34%)
• Similarity: 315/656 - (48%)
• Gaps: 144/656 - (21%)

  Fly    13 PTPHDNDNNSISDE-----------RETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFL 66
            |.|...|.....||           |..|..|..::|:.:||.|.|.|||||||||..:|||||:
  Rat     7 PNPGLEDRIPSLDELEVIEKEEASSRPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFM 71

  Fly    67 VPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWS 131
            :|:.|:||:.||||.::|.|:||..|||::..|..:.|..||:|.|.:.::|.|..|||.||||.
  Rat    72 IPFLILLVLEGIPLLHLEFAIGQRLRKGSVGVWSSIHPALKGVGIASMFVSFMVGLYYNTIIAWV 136

  Fly   132 LRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSS 196
            :.:||.||...|||:.|                    |:           ||    |:|
  Rat   137 MWYFFNSFQEPLPWSEC--------------------PL-----------NQ----NQT------ 160

  Fly   197 LDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTS 261
                  |:||....::|..:..|...||.|..|.|.|:|:|.:.|||...:.:.|....:||.|:
  Rat   161 ------GYVEECAKSSSVDYFWYRETLNISTSISDSGSIQWWILLCLTCAWSVLYVCTIRGIETT 219

  Fly   262 GKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFG 326
            ||.|:.|:..||.||.|.|||||||.|:..||.:..|||.:.:.....|:||..|||:|....||
  Rat   220 GKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNITELSNPNTWLDAGAQVFYSFSLAFG 284

  Fly   327 VLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAH------------TL----- 374
            .|::::|||..|||...|:::.|.||..||..|..|::|::|:.|.            ||
  Rat   285 GLISFSSYNSVHNNCEMDSVIVSIINGFTSVYAATVVYSIIGFRATERFDDCVNTNILTLINGFD 349

  Fly   375 ----GVRIE-------------------------DVAT------EGPGLVFVVYPAAIATMPAST 404
                .|..|                         |:.|      ||.||.|:|:..||..||.|.
  Rat   350 LPEGNVTAENFEAYQHWCNATNPEAYAQLTFQTCDINTFLSEGVEGTGLAFIVFTEAITKMPVSP 414

  Fly   405 FWALIFFMMLLTLGLDSSFGGSEAIITALSD------EFPKIKRNRELFVA----GLFSLYFVVG 459
            .|:::||:||..|||.|.||..|.::..|.|      ::||     ||...    |.:.:.|:..
  Rat   415 LWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLNITPKKWPK-----ELLTGLICLGTYLIAFIFT 474

  Fly   460 LASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWR 524
            |.|    |.|:..|||.||....:|:..|.|..||.::||.:||::||..|||..|..:|||.||
  Rat   475 LNS----GQYWLSLLDSYAGSIPLLIIAFCEMFAVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWR 535

  Fly   525 FVAPIFLLFITVYGLI--------------GYEPLTYADYV-YPSWANALGWCIAGSSVVMIPAV 574
            .|:|:.:|.|.::..:              .||....:..| ||.|..|:...:||...:.||..
  Rat   536 VVSPLIMLVIFLFFFVIEVNKQLMYSVWDPDYEEFPKSQKVPYPDWVYAVVVIVAGVPCLTIPCF 600

  Fly   575 AIFKLL 580
            ||:||:
  Rat   601 AIYKLI 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	219/631 (35%)
Slc6a19	NP_001034811.2	SLC5-6-like_sbd	32..612	CDD:444915	219/631 (35%)