Protein Alignment DAT and SLC6A13

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_057699.2
• Gene: SLC6A13 / 6540
• HGNCID: 11046
• Length: 602
• Species: Homo sapiens
• Alignment Length: 606
• Identity: 267/606 - (44%)
• Similarity: 379/606 - (62%)
• Gaps: 43/606 - (7%)

  Fly    26 ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQH 90
            ||..|:.|::|:|||.|..:.|.|||||||||||||||||.:||.:.|...|||:|.:|.||||:
Human    31 ERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQY 95

  Fly    91 NRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTP 155
            ..:|.:|.|.::.|:|:|||||..:|...::.||.:::||:|.:.|:|||..|||..|.:.|||.
Human    96 TSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTE 160

  Fly   156 NCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYI 220
            :|..|:..|.|                         :||:|         |...|...|::.|.:
Human   161 HCMEFQKTNGS-------------------------LNGTS---------ENATSPVIEFWERRV 191

  Fly   221 LELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLT 285
            |::  |:||..|||::|::|||||:.::||||.:|||:.::||||:|||.|||.:|::|||||:|
Human   192 LKI--SDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVT 254

  Fly   286 LPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSF 350
            |||:..|||:||.||.:.::..:||:||.||:|||.....|.|.|..||||||||.|:|.:...|
Human   255 LPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCF 319

  Fly   351 INSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLL 415
            :||.|||:|||.|||:||:|:...||.|.:||..||||.|:.||.|:..:|.|..||..||.|::
Human   320 LNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVV 384

  Fly   416 TLGLDSSFGGSEAIITALSDEFPKI---KRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRY 477
            .|||||.|...|:::|||.|.:|.:   |..||:.:.|:..:.|:|||...|:||.|.|.|.|.|
Human   385 LLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYY 449

  Fly   478 AA-GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIG 541
            || |..:|....||::.|:|:||..||.::|.||||:.|....:.||.|:.|.......::.||.
Human   450 AASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIK 514

  Fly   542 YEPLTY-ADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD--QQSM 603
            |.|||| ..|.||.|.:||||.:|.||:|.|||.::::|.:..|..|:|...|..|..|  |::.
Human   515 YTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNP 579

  Fly   604 AMVLNGVTTEVTVVRLTDTET 624
            |......|...:::|||:.|:
Human   580 AGPSAPATPRTSLLRLTELES 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	257/574 (45%)
SLC6A13	NP_057699.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22
		SLC6sbd_GAT2	32..575	CDD:271396	259/578 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830