Protein Alignment DAT and SLC6A8

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_005620.1
• Gene: SLC6A8 / 6535
• HGNCID: 11055
• Length: 635
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 260/610 - (42%)
• Similarity: 376/610 - (61%)
• Gaps: 44/610 - (7%)

  Fly    27 RETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHN 91
            ||||:.::||::|.:||||.|.|||||||||||||||.||:||.::.:|||||:|::|::|||..
Human    52 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFM 116

  Fly    92 RKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPN 156
            :.|:|..| .:.|||||:|||.::|.||.:.||.:::||...:...|||.:|||.:|.:.||||:
Human   117 KAGSINVW-NICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPD 180

  Fly   157 CRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYIL 221
            |                         ..:..:|...| :||.......:...:|...|::...:|
Human   181 C-------------------------VEIFRHEDCAN-ASLANLTCDQLADRRSPVIEFWENKVL 219

  Fly   222 ELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTL 286
            .|  |.|:...||:.|::.||||..:::.||.:|||:.::||:|:|||.|||.||::||:||:.|
Human   220 RL--SGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLL 282

  Fly   287 PGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFI 351
            ||:..||.|||.|::|.:...:||:||.||:|||...|.|.|.|..|||:::||.||||::.:.|
Human   283 PGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALI 347

  Fly   352 NSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLT 416
            ||.|||.||||:||:||:||...||.|..||..||||.|:.||.|:..||.:..||.:||.|||.
Human   348 NSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLL 412

  Fly   417 LGLDSSFGGSEAIITALSDEFPK---IKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRY- 477
            |||||.|.|.|..||.|.|..|.   .:..||:.||...:|.||:.|:..|.||.|.|.|.|.|
Human   413 LGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYS 477

  Fly   478 AAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGY 542
            |:|.::|...|:|.:.|:|:||.:||.:||..|||:.|..:.:.||.|..|:..:.|.::.::.|
Human   478 ASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYY 542

  Fly   543 EPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTP-W----RDQQ 601
            |||.|.: ||||.|..|:||..|.||::.:|...:..||...|::.:|:..||.| |    .:.:
Human   543 EPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYR 607

  Fly   602 SMAMVLNGVTTEVTVVRLTDTETAK 626
            :....:.|:||...|     :|::|
Human   608 AQDADVRGLTTLTPV-----SESSK 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	253/575 (44%)
SLC6A8	NP_005620.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		SLC6sbd_CT1	52..621	CDD:271397	257/597 (43%)