Protein Alignment DAT and SLC6A7

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_016865256.1
• Gene: SLC6A7 / 6534
• HGNCID: 11054
• Length: 754
• Species: Homo sapiens
• Alignment Length: 659
• Identity: 279/659 - (42%)
• Similarity: 389/659 - (59%)
• Gaps: 50/659 - (7%)

  Fly     6 HISKSKTP----TPHDNDNNSI----SDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGG 62
            |:.|..||    ||.|..:..:    :..|..|:||:|||||.||:.|.|.|||||||..|.|||
Human    89 HLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGG 153

  Fly    63 GAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVI 127
            |||||||.:||.:.|||||::||:|||.:..|.:..| ::.|||||.|.|::||...|..|||:|
Human   154 GAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMI 217

  Fly   128 IAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYM 192
            ||:.|.:.|||.|:.|||..|.|.|||..|........               ||.:|..|.|..
Human   218 IAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKD---------------GNGALPLNLTCT 267

  Fly   193 NGSSLDTSAVGHVEGFQSA---------------------ASEYFNRYILELNRSEGIHDLGAIK 236
            ...|.:..:..|.|..:..                     |.|..:||:|.:..|:||...|.|:
Human   268 VSPSEEYWSQTHTEAEEEGRRGRVVSNSYPQVIFLPQPPKAEEGVSRYVLHIQGSQGIGSPGEIR 332

  Fly   237 WDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNF 301
            |::.||||:.::|.:..:.||:.:|||||:|||.|||.:||:||:||:||||::.|||:||||.|
Human   333 WNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQF 397

  Fly   302 SAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSV 366
            ..:..::||::||.|:|:|||.|||.||.:||||.:|.|:|:|..:.:..|:.||.:|||.||||
Human   398 HHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSV 462

  Fly   367 LGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIIT 431
            ||||:..|||.::.||..||||.|||||.|:..:|.|.||:.:||.|||||||||.|...|.|:|
Human   463 LGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVT 527

  Fly   432 ALSDEFPKIKRNRELFVAGLFSL-YFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVS 495
            |::||||...|.::...:||..: .:::||...|.||.|:..|||.|:|.:.::|.|....:||:
Human   528 AVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVT 592

  Fly   496 WIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALG 560
            .:||..||..||..|:||.||.|::.||.|::|..||.:.||.::.|:|..|..|.:|.||..||
Human   593 RVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLG 657

  Fly   561 WCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQQSMAMVLNGVTTEVTVVRLTDTETA 625
            ..:...|.:||||..:..:|...|||.:|....:.|..|   ....|....|.:.|..|..:::.
Human   658 ILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMD---WGPSLEENRTGMYVATLAGSQSP 719

  Fly   626 KEPVDVXVR 634
            | |:.| :|
Human   720 K-PLMVHMR 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	262/591 (44%)
SLC6A7	XP_016865256.1	SLC6sbd_PROT	118..699	CDD:271390	264/599 (44%)