Protein Alignment DAT and SLC6A6

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001127839.2
• Gene: SLC6A6 / 6533
• HGNCID: 11052
• Length: 721
• Species: Homo sapiens
• Alignment Length: 625
• Identity: 272/625 - (43%)
• Similarity: 381/625 - (60%)
• Gaps: 50/625 - (8%)

  Fly     8 SKSKTP-TPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGI 71
            |..|:| |..:::......:||.||.|:||:|||.|..|.|.||||||||||||||||||:||.|
Human   122 SPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFI 186

  Fly    72 MLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFF 136
            .|...|:|:|::|:.:||:..:|.||||.::.|||.|||||.|:|...::.||.||:||:..:.|
Human   187 FLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLF 251

  Fly   137 ASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSA 201
            .||...|||..||:.||||:|    .::..|             .|:|:....:..|
Human   252 QSFQKELPWAHCNHSWNTPHC----MEDTMR-------------KNKSVWITISSTN-------- 291

  Fly   202 VGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVW 266
                  |.|...|::.|.:|.|  |.||...|::|||:|||||:|:|:|:|.:|||:.::||||:
Human   292 ------FTSPVIEFWERNVLSL--SPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVY 348

  Fly   267 FTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAY 331
            |||.||:|:||:||:|||||||:..||::||.|:.:.:...:||:||.||:|||.....|.:.:.
Human   349 FTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSL 413

  Fly   332 ASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAA 396
            .|||||..|.|:|.:|...:||.|||::||.|||:||:||...||.|.|||..||||.|:.||.|
Human   414 GSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKA 478

  Fly   397 IATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKR---NRELFVAGLFSLYFVV 458
            :..||..|||:::||:|||.|||||.|...|..||:|.|.:|...|   .||:|:|.:.|:.:::
Human   479 VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLL 543

  Fly   459 GLASCTQGGFYFFHLLDRYAA-GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVC 522
            ||...|:||.|.|.|.|.||| |..:|...|||...::||||.:...:.|.||||:.||.:.:..
Human   544 GLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYS 608

  Fly   523 WRFVAPIFLLFITVYGLIGYEPLTY-ADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSL 586
            |..:.|:..:...::.|:.|.|||| ..||||:||..|||.:|.||::.:|.|.:.:|..|.|..
Human   609 WAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPF 673

  Fly   587 RQRFTILTTP-----WRDQQSMA------MVLNGVTTEVT 615
            ..|...|.||     |..::..|      .|:||...:.|
Human   674 LVRVKYLLTPREPNRWAVEREGATPYNSRTVMNGALVKPT 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	262/579 (45%)
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	260/573 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830