DRSC/TRiP Functional Genomics Resources

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Protein Alignment DAT and SLC6A4

DIOPT Version :9

Sequence 1:NP_001261026.1 Gene:DAT / 36849 FlyBaseID:FBgn0034136 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_001036.1 Gene:SLC6A4 / 6532 HGNCID:11050 Length:630 Species:Homo sapiens


Alignment Length:611 Identity:298/611 - (48%)
Similarity:406/611 - (66%) Gaps:54/611 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 TGHISK--SKTPTP--HDNDNNSI------------SDERETWSGKVDFLLSVIGFAVDLANVWR 52
            :|.||.  |..|:|  .|:..:||            ..|||||..||||||||||:||||.||||
Human    40 SGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWR 104

  Fly    53 FPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIA 117
            |||:||:|||||||:||.||.:.||||||||||||||::|.|.|:.|.::.|:|||||||:.:||
Human   105 FPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIA 169

  Fly   118 FYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGN 182
            ||:..|||.|:||:|.:..:|||:.||||||.|.|||.||..:.|::                  
Human   170 FYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSED------------------ 216

  Fly   183 QSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVY 247
                 |.|:...|:             |.|.|::.|::|:::||:|:.|||.|.|.:|||:::::
Human   217 -----NITWTLHST-------------SPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIF 263

  Fly   248 LICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVD 312
            .:.|||:|||:.|||||||.||.|||.:|.:||:||.||||::.|:.:||.||:..:.:..||:|
Human   264 TVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWID 328

  Fly   313 AATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVR 377
            ||.|:|||||||||||||:|||||::||.|:|||:||.:|..|||::|||||:||||||......
Human   329 AAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNED 393

  Fly   378 IEDVATE-GPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKI- 440
            :.:||.: ||.|:|:.|..|||.||||||:|:|||:||:||||||:|.|.|.:|||:.||||.: 
Human   394 VSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVW 458

  Fly   441 KRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSE 505
            .:.||.||..:....|...|.:.|.||.|...||:.||.|.::|.....||:||||.||..:|..
Human   459 AKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCR 523

  Fly   506 DIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVM 570
            |:::|:||.||.:|::||..::|:|||||....|:....|....|.||.|:..||:||..||.:.
Human   524 DVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFIC 588

  Fly   571 IPAVAIFKLLSTPGSLRQRFTILTTP 596
            ||....::|:.|||:.::|.....||
Human   589 IPTYIAYRLIITPGTFKERIIKSITP 614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DATNP_001261026.1 SLC6sbd_SERT-like_u1 27..597 CDD:271405 288/572 (50%)
SLC6A4NP_001036.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..59 7/18 (39%)
5HT_transport_N 24..64 CDD:397524 8/23 (35%)
SLC6sbd_SERT 79..615 CDD:271399 288/572 (50%)
Interaction with RAB4A 616..624
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53371
OrthoDB 1 1.010 - - D250396at2759
OrthoFinder 1 1.000 - - FOG0000975
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101590
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X639
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.830

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