DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and SLC6A3

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001035.1	Gene:	SLC6A3 / 6531	HGNCID:	11049	Length:	620	Species:	Homo sapiens

Alignment Length:	593	Identity:	306/593 - (51%)
Similarity:	406/593 - (68%)	Gaps:	35/593 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALG 88
            :.:||||..|:|||||||||||||||||||||||||||||||||||.:.:|:.|:||||||||||
Human    57 AQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALG 121

  Fly    89 QHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWN 153
            |.||:||...| ::.|:.||:|:.|:||:.||.|:|||||||:|.:.|:|||..|||..|||.||
Human   122 QFNREGAAGVW-KICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWN 185

  Fly   154 TPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNR 218
            :|||                              ::.:...||.|:|.:....| .:.|:|||.|
Human   186 SPNC------------------------------SDAHPGDSSGDSSGLNDTFG-TTPAAEYFER 219

  Fly   219 YILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRG 283
            .:|.|::|.||.|||..:|.:..||::|.::.|||||||:.|||||||.||..||.||..||:||
Human   220 GVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRG 284

  Fly   284 LTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLT 348
            :||||:..||:.||:.:|..:.:|.||:||||||.||||.|||||:|::||||:.||.|:||::|
Human   285 VTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVT 349

  Fly   349 SFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMM 413
            :.|||.|||.:|||:||.|||||....|.|.|||.:||||:|::||.||||:|.|:.||::||:|
Human   350 TSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIM 414

  Fly   414 LLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYA 478
            |||||:||:.||.|::||.|.|||..:.|:||||...:....|::.|...|.||.|.|.|||.:|
Human   415 LLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFA 479

  Fly   479 AGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYE 543
            ||.|||..|..|||.|:|.||..:||:||:.|.|..|..||::||:.|:|.||||:.|..::.:.
Human   480 AGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFR 544

  Fly   544 PLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQQSMAMVLN 608
            |..|..|::|.|||||||.||.||:.|:|..|.:|..|.|||.|::......|.:|::   :|..
Human   545 PPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRE---LVDR 606

  Fly   609 GVTTEVTV 616
            |...:.|:
Human   607 GEVRQFTL 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	301/569 (53%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	305/588 (52%)
SLC6A3	NP_001035.1	Interaction with TGFB1I1. /evidence=ECO:0000269\|PubMed:12177201	561..590		15/28 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	665	1.000	Domainoid score	I150
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	677	1.000	Inparanoid score	I722
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	1	1.000	-	-		otm41765
orthoMCL	1	0.900	-	-		OOG6_101590
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840