DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and SLC6A2

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001165975.1	Gene:	SLC6A2 / 6530	HGNCID:	11048	Length:	628	Species:	Homo sapiens

Alignment Length:	590	Identity:	330/590 - (55%)
Similarity:	422/590 - (71%)	Gaps:	35/590 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIP 79
            |.|.|    :..||||..|:||||||:|||||||||||||||||||||||||:||.:.|::.|:|
Human    48 PRDGD----AQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMP 108

  Fly    80 LFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLP 144
            ||||||||||:||:||.|.| ::.|.|||:||||:|||.||.|||||||||||.:.|:|||.:||
Human   109 LFYMELALGQYNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLP 172

  Fly   145 WTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQ 209
            ||.|.:.||:|||...:..|.|   |:||::. |:.      |..|
Human   173 WTDCGHTWNSPNCTDPKLLNGS---VLGNHTK-YSK------YKFT------------------- 208

  Fly   210 SAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYA 274
             .|:|::.|.:|.|:.|.||||:|..:|.:.|||::|.::.|||||||:.|||||||.||..||.
Human   209 -PAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYF 272

  Fly   275 VLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHN 339
            ||.:||:.|:||||:..||..||..:|..:.:|.||:|||||:|||||.|||||:|:|||||:.|
Human   273 VLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDN 337

  Fly   340 NVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPAST 404
            |.|:||||||.||..|||::||.|||:||||||...|.||||||||.||||::||.||:|:..||
Human   338 NCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGST 402

  Fly   405 FWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFY 469
            |||::||:|||.||||||.||.||:||.|:|:|..:||:|:||..|:....|::.|...|:||.|
Human   403 FWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIY 467

  Fly   470 FFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFI 534
            ...|||.:|||.|||.||..|||.|||.||.:|||.||:.|:||.||.||::||:||:|.||||:
Human   468 VLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFV 532

  Fly   535 TVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD 599
            .|..:|.::||||.||::|.|||.:||.||.||:|::|...|:|.|||.|||.:|.....||..:
Human   533 VVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENE 597

  Fly   600 QQSMA 604
            ...:|
Human   598 HHLVA 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	325/569 (57%)
SLC6A2	NP_001165975.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
SLC6A2	NP_001165975.1	SLC6sbd_NET	56..612	CDD:212081	327/578 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	665	1.000	Domainoid score	I150
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H816
Inparanoid	1	1.050	677	1.000	Inparanoid score	I722
Isobase	1	0.950	-	0	Normalized mean entropy	S2872
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	1	1.000	-	-		otm41765
orthoMCL	1	0.900	-	-		OOG6_101590
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2688
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820