Protein Alignment DAT and SLC6A1

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 261/608 - (42%)
• Similarity: 380/608 - (62%)
• Gaps: 55/608 - (9%)

  Fly     5 GHISKSKTPTPHDND---------NNSISD--ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCY 58
            |.||...:..|..||         ....:|  :|:||.|:.|||:|.:|:|:.|.|||||||||.
Human    11 GQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCG 75

  Fly    59 KNGGGAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFY 123
            ||||||||:||.:.|:..|:|||.:|.:|||:...|.:..| :|.|:|||:|.|..:::|:::.|
Human    76 KNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVW-KLAPMFKGVGLAAAVLSFWLNIY 139

  Fly   124 YNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYN 188
            |.|||:|::.:.:.|||.:|||..|:|.|||..|             ..|||          :.|
Human   140 YIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRC-------------FSNYS----------MVN 181

  Fly   189 ETYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFS 253
            .|.|.                ||..|::.|.:.::  ::|:...|.|:|.:|:.|.|.:::.||.
Human   182 TTNMT----------------SAVVEFWERNMHQM--TDGLDKPGQIRWPLAITLAIAWILVYFC 228

  Fly   254 LWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVF 318
            :|||:..:||||:|:|.:||.:|:||..||:||||:..||.:|:||||..:..:|||:|||||:|
Human   229 IWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIF 293

  Fly   319 FSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVAT 383
            ||.|.|.|.|:|..|||.:|||||:|:::...|||.||..|||||||::|:|||.....|.|||.
Human   294 FSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAA 358

  Fly   384 EGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRN-RELF 447
            .||||.|:.||.|:..:|.|..||::||.|||.||:||.|...|..||||.||:|::.|| ||||
Human   359 SGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELF 423

  Fly   448 VAGLFSLYFVVGLASCTQGGFYFFHLLDRY-AAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMI 511
            :|.:..:.:::||::.||||.|.|.|.|.| |:|.|:|..||||.:::||.||.|||.::|::|:
Human   424 IAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMV 488

  Fly   512 GFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAI 576
            |..|..:|::||.|..||.:..:.::..:...|||..:||:|.|...:||.:|.||:|:||....
Human   489 GSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMA 553

  Fly   577 FKLLSTPGSLRQRFTILTTPWRD 599
            :..|:..|||:||..::..|..|
Human   554 YMFLTLKGSLKQRIQVMVQPSED 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	252/571 (44%)
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	261/608 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		261/608 (43%)
		PDZ-binding	597..599