Protein Alignment DAT and Slc6a17

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001028251.1
• Gene: Slc6a17 / 613226
• RGDID: 1587185
• Length: 727
• Species: Rattus norvegicus
• Alignment Length: 637
• Identity: 225/637 - (35%)
• Similarity: 330/637 - (51%)
• Gaps: 127/637 - (19%)

  Fly    24 SDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALG 88
            :::|..|:.|:.::|:.|||:|.|.|:|||||||.||||||:||||.::|::.|||||::|||:|
  Rat    57 AEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVG 121

  Fly    89 QHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWN 153
            |..|:|:|..|..:.|...|||::..::..:|..||||||.||:.:||.||...|||:.|
  Rat   122 QRIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGLYYNVIIGWSVFYFFKSFQYPLPWSEC----- 181

  Fly   154 TPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNR 218
                           |||.|                        .|.||...|..:|:|:.|| .
  Rat   182 ---------------PVIRN------------------------GTVAVVEPECEKSSATTYF-W 206

  Fly   219 YILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRG 283
            |...|:.|..|.:.|.:.|.|.:|||:.:.|...::.|||.:||||::|::||||.||...|:||
  Rat   207 YREALDISNSISESGGLNWKMTVCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRG 271

  Fly   284 LTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLT 348
            |.|.|:..||.:..||....:...:||.:|||||||:||.|||.::|::||||..||.:.||.|.
  Rat   272 LLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALV 336

  Fly   349 SFINSATSFIAGFVIFSVLGYMAHTLGVR--IE-------------------------------- 379
            ||||..||.:|..|:|:|||:.|:.:..:  :|
  Rat   337 SFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIPPHVNFSHLTTKD 401

  Fly   380 ------------------------------DVATEGPGLVFVVYPAAIATMPASTFWALIFFMML 414
                                          |.:.:|.||.|:.:..|:...|||.||:::||:||
  Rat   402 YSEMYNVIMTVKEKQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML 466

  Fly   415 LTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAA 479
            :.|||.|..|....|.|.:.|.|   |..:|:|..|.....|.|||....:.|.||..:.|.|:|
  Rat   467 INLGLGSMIGTMAGITTPIIDTF---KVPKEMFTVGCCVFAFFVGLLFVQRSGNYFVTMFDDYSA 528

  Fly   480 GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLI--GY 542
            ...:.|.|..|.|||:|||||.:|.:::.:|:||.|.|::...|:||:|:.:..:|...:|  |.
  Rat   529 TLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGV 593

  Fly   543 EPLTYADYV----------YPSWANALGWCIAGSSVVMIPAVAI---FKLLS 581
            .|..|:.::          :|:||.||...:...:.:.||.|.|   |.|||
  Rat   594 SPPGYSAWIKEEAAERYLYFPNWAMALLITLIAVATLPIPVVFILRHFHLLS 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	225/634 (35%)
Slc6a17	NP_001028251.1	SLC6sbd_NTT4	60..648	CDD:271403	225/634 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..727

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820