DRSC/TRiP Functional Genomics Resources

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Protein Alignment DAT and Slc6a17

DIOPT Version :10

Sequence 1:NP_001261026.1 Gene:DAT / 36849 FlyBaseID:FBgn0034136 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_001028251.1 Gene:Slc6a17 / 613226 RGDID:1587185 Length:727 Species:Rattus norvegicus


Alignment Length:637 Identity:225/637 - (35%)
Similarity:330/637 - (51%) Gaps:127/637 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 SDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALG 88
            :::|..|:.|:.::|:.|||:|.|.|:|||||||.||||||:||||.::|::.|||||::|||:|
  Rat    57 AEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVG 121

  Fly    89 QHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWN 153
            |..|:|:|..|..:.|...|||::..::..:|..||||||.||:.:||.||...|||:.|     
  Rat   122 QRIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGLYYNVIIGWSVFYFFKSFQYPLPWSEC----- 181

  Fly   154 TPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNR 218
                           |||.|                        .|.||...|..:|:|:.|| .
  Rat   182 ---------------PVIRN------------------------GTVAVVEPECEKSSATTYF-W 206

  Fly   219 YILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRG 283
            |...|:.|..|.:.|.:.|.|.:|||:.:.|...::.|||.:||||::|::||||.||...|:||
  Rat   207 YREALDISNSISESGGLNWKMTVCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRG 271

  Fly   284 LTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLT 348
            |.|.|:..||.:..||....:...:||.:|||||||:||.|||.::|::||||..||.:.||.|.
  Rat   272 LLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALV 336

  Fly   349 SFINSATSFIAGFVIFSVLGYMAHTLGVR--IE-------------------------------- 379
            ||||..||.:|..|:|:|||:.|:.:..:  :|                                
  Rat   337 SFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIPPHVNFSHLTTKD 401

  Fly   380 ------------------------------DVATEGPGLVFVVYPAAIATMPASTFWALIFFMML 414
                                          |.:.:|.||.|:.:..|:...|||.||:::||:||
  Rat   402 YSEMYNVIMTVKEKQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML 466

  Fly   415 LTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAA 479
            :.|||.|..|....|.|.:.|.|   |..:|:|..|.....|.|||....:.|.||..:.|.|:|
  Rat   467 INLGLGSMIGTMAGITTPIIDTF---KVPKEMFTVGCCVFAFFVGLLFVQRSGNYFVTMFDDYSA 528

  Fly   480 GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLI--GY 542
            ...:.|.|..|.|||:|||||.:|.:::.:|:||.|.|::...|:||:|:.:..:|...:|  |.
  Rat   529 TLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGV 593

  Fly   543 EPLTYADYV----------YPSWANALGWCIAGSSVVMIPAVAI---FKLLS 581
            .|..|:.::          :|:||.||...:...:.:.||.|.|   |.|||
  Rat   594 SPPGYSAWIKEEAAERYLYFPNWAMALLITLIAVATLPIPVVFILRHFHLLS 645

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DATNP_001261026.1 SLC6sbd_SERT-like_u1 27..597 CDD:271405 225/634 (35%)
Slc6a17NP_001028251.1 SLC6sbd_NTT4 60..648 CDD:271403 225/634 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 680..727
Blue background indicates that the domain is not in the aligned region.

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