DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and slc6a6b

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001032750.1	Gene:	slc6a6b / 569098	ZFINID:	ZDB-GENE-030131-3077	Length:	625	Species:	Danio rerio

Alignment Length:	597	Identity:	266/597 - (44%)
Similarity:	370/597 - (61%)	Gaps:	39/597 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SKSKTP-TPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGI 71
            |..|:| |..:::......:||.|:.|:||||||.|..|.|.||||||||||||||||||:||.|
Zfish    21 SPGKSPGTRPEDEAEGKHPQREKWASKLDFLLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFI 85

  Fly    72 MLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFF 136
            .|..||:|:|::|:||||...:|.||||.:|.|:|.|||||.::|...::.||.||:||.|.:.|
Zfish    86 FLFGGGLPVFFLEVALGQFTSEGGITCWEKLCPIFTGIGYASIVIVSLLNIYYIVILAWGLYYLF 150

  Fly   137 ASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSA 201
            ..|...|||.||||.|||.||                       ...:|..|:|..        |
Zfish   151 QCFQPELPWASCNNKWNTENC-----------------------VEDTLRRNKTLW--------A 184

  Fly   202 VGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVW 266
            ..:...|.|..:|::.|.:|.:  |:||.::|.:|||:|||||.:::||:|.:|||:.::||||:
Zfish   185 AANATNFTSPVTEFWERNVLSI--SDGIEEVGHVKWDLALCLLAMWVICFFCVWKGVKSTGKVVY 247

  Fly   267 FTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAY 331
            .||.||:.:|::||:||:||||:..||::||.||.:.:...|||:||.||:|||.....|.:.:.
Zfish   248 VTATFPFVMLIVLLVRGVTLPGAAEGIKFYLYPNVTRLGDPEVWIDAGTQIFFSYAICLGAMTSL 312

  Fly   332 ASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAA 396
            .|||||..|.|:|.||...:||||||::||.||||||:||...||.|.|||..||||.|:.||.|
Zfish   313 GSYNKYKYNCYRDCLLLGGLNSATSFVSGFAIFSVLGFMAQEQGVDIADVAESGPGLAFIAYPKA 377

  Fly   397 IATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKR---NRELFVAGLFSLYFVV 458
            :..||..||||::||:|||.|||||.|...|..||:|.|.:|...|   .||:|:|.:..:.:::
Zfish   378 VTMMPLPTFWAILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAIVCFVSYLL 442

  Fly   459 GLASCTQGGFYFFHLLDRYAA-GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVC 522
            ||...|:||.|.|.|.|.||| |..:|...|||.|||:|:||.:.|.:.|.:|||:.|..:.:..
Zfish   443 GLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECIAVAWVYGADNFYDAIEEMIGYRPNPWMKWS 507

  Fly   523 WRFVAPIFLLFITVYGLIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSL 586
            |..|.|...:...::.|:.|.||.|.. |.||.|:..:||.:|.:|::.||.|.:.|::.:.|.|
Zfish   508 WTVVTPFLCVGCFIFSLVKYAPLRYNKIYEYPDWSIGVGWTLALASMICIPMVVVIKIIQSDGPL 572

  Fly   587 RQRFTILTTPWR 598
            .:|...:..|.|
Zfish   573 IERIKAVAAPVR 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	260/574 (45%)
slc6a6b	NP_001032750.1	SLC6sbd_TauT	41..582	CDD:271398	260/573 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930