Protein Alignment DAT and Slc6a14

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_064433.3
• Gene: Slc6a14 / 56774
• MGIID: 1890216
• Length: 638
• Species: Mus musculus
• Alignment Length: 592
• Identity: 269/592 - (45%)
• Similarity: 367/592 - (61%)
• Gaps: 34/592 - (5%)

  Fly    17 DNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLF 81
            :||.|   .||..||.|.|:|||::|:||.|.||||||||.|.|||||||:||.|||.:.|:|||
Mouse    29 ENDEN---QERGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLF 90

  Fly    82 YMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWT 146
            ::|.:|||....|.::.| |::|||:|:|..:|||:.:|..|||||||:||.:.||||.:.|||.
Mouse    91 FLECSLGQFASLGPVSVW-RILPLFQGVGITMVLISVFVAIYYNVIIAYSLYYLFASFQSVLPWA 154

  Fly   147 SCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGF--- 208
            :|:: |...||        ||.|::...       |.|:...|.:||.|.::|:.:..:.|.
Mouse   155 NCSS-WADENC--------SRTPIVTGC-------NVSIGAGEMFMNISWVNTNNLTCLNGSEVF 203

  Fly   209 ---QSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTAL 270
               |..:.:|:::  :.|.||.|:.:.|.:.|.:|||||:.:||...:|:|||.:|||||:||||
Mouse   204 RPGQLPSEQYWDK--VTLQRSSGMDETGVVVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTAL 266

  Fly   271 FPYAVLLILLIRGLTLPGSFLGIQYYL--TPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYAS 333
            |||.|||||||||.||.|:..||.||:  ..||:.:.:||||.|||||:|:||...:|.|:|.:|
Mouse   267 FPYVVLLILLIRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSS 331

  Fly   334 YNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIA 398
            |||::||.|.||::....|..||..|||.|||:||:|||..|..:..|...|..|.|:.||.|:|
Mouse   332 YNKFNNNCYSDAIIVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALA 396

  Fly   399 TMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPK-IKRNRELFVAGLFSLYFVVGLAS 462
            .:||..||:::||.|||||||||.|...|.|.|...|.||| :||.|.....|...:.|::||..
Mouse   397 QLPAGPFWSILFFFMLLTLGLDSQFASIETITTTFQDLFPKAMKRMRVPITLGCCLILFLLGLLC 461

  Fly   463 CTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPP---GRYWQVCWR 524
            .||.|.|:.||:|.:.||:.||:|...|...:.||||.|||.|||..|||...   ..:|:.||.
Mouse   462 VTQAGIYWVHLIDHFCAGWGILIAAILEIAGIIWIYGGNRFIEDIEMMIGAKRWIFWLWWRACWF 526

  Fly   525 FVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQR 589
            .:.||.|..|.|:.|:.:....|||..||.|..|||||:....::.||.:||.|::...|::.||
Mouse   527 VITPILLSAILVWSLVKFHRPDYADIPYPDWGVALGWCMIIFCIIWIPIMAIIKIVQAEGNILQR 591

  Fly   590 FTILTTP 596
            ......|
Mouse   592 IISCCRP 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	265/582 (46%)
Slc6a14	NP_064433.3	SLC5-6-like_sbd	36..637	CDD:294310	265/582 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	618..638

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820