Protein Alignment DAT and slc6a8

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001314797.1
• Gene: slc6a8 / 567544
• ZFINID: ZDB-GENE-071024-2
• Length: 652
• Species: Danio rerio
• Alignment Length: 634
• Identity: 273/634 - (43%)
• Similarity: 396/634 - (62%)
• Gaps: 54/634 - (8%)

  Fly     4 TGHIS---KSKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAF 65
            ||.||   |.:...|          |||||:.::||::|.:||||.|.|||||||||||||||.|
Zfish    48 TGAISAVEKKREGYP----------ERETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVF 102

  Fly    66 LVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAW 130
            |:||.:.:.:||||:|::|:||||..:.|:|..| .:.|||||:|||.::|.|:.:.||.:::||
Zfish   103 LIPYVLFIFLGGIPIFFLEIALGQFMKAGSINVW-NIAPLFKGLGYASMVIVFFCNTYYIMVLAW 166

  Fly   131 SLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGS 195
            ...:|..||..:|||::|:|.|||.||.....|...:...|||.:    .||   |..|...||
Zfish   167 GFYYFIKSFNATLPWSTCDNPWNTENCIEIFRQGDCKNGTIGNST----FGN---LTCEELANG- 223

  Fly   196 SLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGIST 260
                         :|...|::...:  ||.|:|:.:.||:.|::.||||.|:::.||.:|||:.:
Zfish   224 -------------RSPIIEFWENKV--LNISDGLDEPGAVNWELMLCLLAVWVMVYFCVWKGVKS 273

  Fly   261 SGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGF 325
            :||:|:|||.|||.||:|||:||:||||::.||.||:.|::|.:.:|:||:||.||:|||...|.
Zfish   274 TGKIVYFTATFPYVVLIILLVRGVTLPGAYDGILYYVKPDWSKLGEAQVWIDAGTQIFFSYAIGL 338

  Fly   326 GVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVF 390
            |.|.|..|||:::|:.||||.:.:.|||.|||.||||:||:||:||...||.|..||..||||.|
Zfish   339 GALTALGSYNRFNNDCYKDAFVLALINSGTSFFAGFVVFSILGFMASEQGVDISKVAESGPGLAF 403

  Fly   391 VVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFP---KIKRNRELFVAGLF 452
            :.||.|::.||.:..||.:||:|||.|||||.|.|.|..:|.:.|.||   .::..||:.||...
Zfish   404 IAYPKAVSMMPVAPVWAALFFIMLLLLGLDSQFVGVEGFVTGILDLFPGKYYMRYQREIAVAICC 468

  Fly   453 SLYFVVGLASCTQGGFYFFHLLDRY-AAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPG 516
            .|.|::.|:..||||.|.|.|.|.| |:|.::|...|:|.:.|:|:||.:||.:||..|||:.|.
Zfish   469 LLCFIIDLSMVTQGGMYVFQLFDYYSASGMTLLWQAFWECVVVAWVYGADRFMDDIARMIGYRPF 533

  Fly   517 RYWQVCWRFVAPIFLLFITVYGLIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLL 580
            .:.:.||..:.|...:.|.::.|:.|:||||.: ||||.|...:|||:|.||::.||...::||.
Zfish   534 PWMKWCWSIITPCVCMGIFLFHLLNYKPLTYNNVYVYPWWGEVIGWCLALSSMLCIPVSLVYKLS 598

  Fly   581 STPGSLRQRFTILTTP-W-----------RDQQSMAMVLNGVTTEVTVV 617
            ...|:.::|:..||.| |           .|.:|:|.:..|:.....::
Zfish   599 GAKGTFKERWENLTKPVWGAHHLEYMAPDTDIKSLASLSPGMEENKVII 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	261/575 (45%)
slc6a8	NP_001314797.1	SLC6sbd_CT1	64..652	CDD:271397	266/608 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.830