DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and slc6a2

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_009301625.1	Gene:	slc6a2 / 565776	ZFINID:	ZDB-GENE-110408-4	Length:	625	Species:	Danio rerio

Alignment Length:	579	Identity:	316/579 - (54%)
Similarity:	407/579 - (70%)	Gaps:	31/579 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQH 90
            |||||..|:||||||||||||||||||||||||||||||||:||.:.|.:.|:|||||||||||:
Zfish    63 ERETWGKKMDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYVLFLFIAGMPLFYMELALGQY 127

  Fly    91 NRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTP 155
            ||:||.|.| ::.|:|||:||.|::||.||.|||||||||||.:.:||.|:.|||..|||.||:|
Zfish   128 NREGAATLW-KICPVFKGVGYTVIVIALYVGFYYNVIIAWSLYYLYASLTSELPWLHCNNPWNSP 191

  Fly   156 NCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYI 220
            ||...:..|.:   |:||       |.....|..|                    .|:|::.|.:
Zfish   192 NCTEPKDINGT---VLGN-------GTSYAKYKNT--------------------PAAEFYERGV 226

  Fly   221 LELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLT 285
            |..:.|:||.|||..:|::.:||::|..|.|||||||:.:|||||:.||..||.|||:|||||:|
Zfish   227 LHSHESKGIGDLGLPRWELTICLVVVAFILYFSLWKGVKSSGKVVYITATMPYIVLLVLLIRGIT 291

  Fly   286 LPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSF 350
            |||:..||:.||..:...:...:||:|||||:|||||.|||||:|::||||::||.|:||:|||.
Zfish   292 LPGAMNGIRAYLHIDLKKLNNPQVWIDAATQIFFSLGAGFGVLIAFSSYNKFNNNCYRDAILTST 356

  Fly   351 INSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLL 415
            ||..|||.:||.|||||||||....|.|:||||||.|||||:||.||:|:|.:||:|::||:|||
Zfish   357 INCVTSFFSGFAIFSVLGYMAEQHKVNIKDVATEGAGLVFVIYPEAISTLPGATFFAIVFFIMLL 421

  Fly   416 TLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAG 480
            |||:|||.||.||::|.|||:|..:||||:||........|::.|...|.||.|...|||:||||
Zfish   422 TLGIDSSMGGMEAVLTGLSDDFKILKRNRKLFTFATVVGTFLMALLCVTNGGIYVLTLLDKYAAG 486

  Fly   481 YSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPL 545
            .|||..|.||||.|||.||.:||||||..|:||.||.||::||:||:|.|||.:.:..::....|
Zfish   487 TSILFGVLFEAIGVSWFYGVDRFSEDIERMMGFKPGIYWRLCWKFVSPAFLLLVVIASIVTSGRL 551

  Fly   546 TYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQQSMA 604
            ||.:||:|.||:.|||.||.||::.:|..||:|..|.|.|.::|.....||..:...:|
Zfish   552 TYDEYVFPYWADMLGWSIALSSMLFVPFYAIYKFFSVPSSFKERLAYCVTPEHEHHLVA 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	313/569 (55%)
slc6a2	XP_009301625.1	SLC5-6-like_sbd	64..623	CDD:294310	315/578 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	637	1.000	Domainoid score	I160
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H816
Inparanoid	1	1.050	651	1.000	Inparanoid score	I773
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	1	1.000	-	-		otm25764
orthoMCL	1	0.900	-	-		OOG6_101590
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.980