Protein Alignment DAT and slc6a7

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001074049.1
• Gene: slc6a7 / 562050
• ZFINID: ZDB-GENE-070112-1492
• Length: 537
• Species: Danio rerio
• Alignment Length: 575
• Identity: 224/575 - (38%)
• Similarity: 317/575 - (55%)
• Gaps: 73/575 - (12%)

  Fly    72 MLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFF 136
            ||...|:|||.|||:|||:...|.||.| :..||.||||..::.::..|..||||||||:..:..
Zfish     1 MLFFTGMPLFLMELSLGQYGAAGPITVW-KCCPLLKGIGIGMLCVSTLVCLYYNVIIAWTFYYLG 64

  Fly   137 ASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSA 201
            :||.:.||| ||:                             |:.|.:|..|:|
Zfish    65 SSFQSPLPW-SCD-----------------------------ALQNIALCANKT----------- 88

  Fly   202 VGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVW 266
                ...||.:..::|..:|.:..|.|:.|.|.::|.:|||||..::|.:..:.|||.:|||||:
Zfish    89 ----NSTQSPSEVFWNEKVLGVVHSTGLSDPGPVRWPLALCLLAAWIIIFLCMLKGIHSSGKVVY 149

  Fly   267 FTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAY 331
            .||.|||.|||:|:|||.||.||..|:.:||||.:..:..|:||.|||:|:|:|||.|.|.||:.
Zfish   150 LTATFPYFVLLVLIIRGATLEGSLDGVAFYLTPKWDQLADAQVWNDAASQIFYSLGIGVGGLLSM 214

  Fly   332 ASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAA 396
            |||||:.|||.:|.::.:..|.:|||.|||.|||:||:||...||.::.||..||||.||.||.|
Zfish   215 ASYNKFDNNVIRDTIIITIGNCSTSFFAGFAIFSILGHMAFKKGVPVDKVADSGPGLAFVAYPEA 279

  Fly   397 IATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRN---RELFVAGLFSLYFVV 458
            :|.:|.|.||:::||:||..||:|:.||..|.|.||:.||||:::.|   :.||:|.|...::::
Zfish   280 LALLPGSVFWSILFFLMLFMLGVDTLFGNMEGICTAVLDEFPQLRSNLKHKTLFLAVLCFSFYLM 344

  Fly   459 GLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMI-GFPPG-----R 517
            ||...|.||.|:|.|:|.::..:.:::...|..|.:|:.||.|:|.:||.||| ..||.     .
Zfish   345 GLLLITDGGIYWFTLIDSFSTSFGLIIITLFMCIGISFFYGVNQFCQDIVDMICRCPPWCTKMLL 409

  Fly   518 YWQVCWRFVAPIFLLFITVYGLIGY--EPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLL 580
            |::.||....|..|.||..|..|..  ..|.|..||||.|..|||.|:.....:.|...||..:.
Zfish   410 YFKACWVVFTPFLLTFILTYIFIEMYRTSLRYGSYVYPIWGKALGVCMGALCCLQILIWAIVAIS 474

  Fly   581 STPGSLRQRFTILTTP---WR---------DQQSMAMVLNGVTTEVTVVRLTDTE 623
            ...|:|:.||.....|   ||         :|......:.|..|    |.||:.:
Zfish   475 KESGTLKDRFKKSIRPLNSWRVNNINSSSQEQHVEPHTIEGPFT----VNLTEAD 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	216/538 (40%)
slc6a7	NP_001074049.1	SLC5-6-like_sbd	1..495	CDD:444915	216/539 (40%)