Protein Alignment DAT and slc6a22.2

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_068077846.1
• Gene: slc6a22.2 / 561024
• ZFINID: ZDB-GENE-030616-628
• Length: 619
• Species: Danio rerio
• Alignment Length: 624
• Identity: 266/624 - (42%)
• Similarity: 372/624 - (59%)
• Gaps: 55/624 - (8%)

  Fly     5 GHISKSKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPY 69
            |.:.|::...|          .||.|:.|::|||:|.|..:.|.|||||||||||||||||.|||
Zfish    27 GALVKARPKPP----------AREQWANKLEFLLAVAGHIIGLGNVWRFPYLCYKNGGGAFFVPY 81

  Fly    70 GIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRF 134
            .:.|...|||||::|.:|||...:|.||||.::.|||:|:|:...::..|...||.:|:||:..:
Zfish    82 VLFLFTCGIPLFFLETSLGQFTSQGGITCWRKICPLFEGLGFGSQVVVLYTGVYYIIILAWAFLY 146

  Fly   135 FFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDT 199
            .|:|||:.|||.||||.||||:|..|...|      |..||.           |:|        |
Zfish   147 LFSSFTSELPWASCNNYWNTPSCMEFSESN------ITEYSP-----------NKT--------T 186

  Fly   200 SAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKV 264
            |.|          .|::.|.||.|  |.||..:|.::||:|||||:.::||||.:|||:.::|||
Zfish   187 SPV----------IEFWERRILGL--SGGIEQIGNVRWDLALCLLLAWIICYFCVWKGVKSTGKV 239

  Fly   265 VWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLL 329
            |:|||.|||.:|::||:|||||||:..||.:||.|:.|.:...:||:||.:|:|:|.|...|||.
Zfish   240 VYFTATFPYLMLIVLLVRGLTLPGAINGITFYLYPDPSRLKDPQVWMDAGSQIFYSYGVCTGVLT 304

  Fly   330 AYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYP 394
            |..|||||.||.|:|.:....:||.|||:|||.||||||:||...||.|..||..||||.|:.||
Zfish   305 ALGSYNKYDNNCYRDCVYLCLLNSLTSFVAGFAIFSVLGFMADEQGVDISLVAESGPGLAFIAYP 369

  Fly   395 AAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFP---KIKRNRELFVAGLFSLYF 456
            .|:|.||....||:.||:|::.|||||.|...||::|::||.:|   ::...|:..:..:.|..|
Zfish   370 RAVALMPLPQLWAIFFFIMIIFLGLDSEFVYQEALVTSISDMYPSFFQVGHRRKFLLLFICSASF 434

  Fly   457 VVGLASCTQGGFYFFHLLDRYA-AGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQ 520
            .|||...|:||.|.|.|.|.|| :|.::|.....::|.|.|:||.:|..:.:.||||:.|..:.:
Zfish   435 FVGLLMVTEGGLYVFQLFDYYACSGMTLLTFAILQSICVGWVYGADRHYDCVEDMIGYRPWPFMK 499

  Fly   521 VCWRFVAPIFLLFITVYGLIGYEPLTY-ADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPG 584
            .||:::.|.......::.|:.|.||.: .:|.||.|..|:|.....||.:::|...|:.:.:|||
Zfish   500 CCWKYLTPAICTGTFIFSLVQYTPLKFNNEYEYPWWGYAIGGFFTLSSTLLVPLWMIYLVGTTPG 564

  Fly   585 SLRQRFTILTTPWR---DQQSMAMVLNGVTTEVTVVRLT 620
            |:|||...|.||..   |.:.....||..|.|.....||
Zfish   565 SMRQRVRALCTPAEDLPDPKCPKQKLNTATFETFTDLLT 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	255/574 (44%)
slc6a22.2	XP_068077846.1	SLC6sbd-TauT-like	39..576	CDD:271387	254/573 (44%)