DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and slc6a11a

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001091857.1	Gene:	slc6a11a / 558960	ZFINID:	ZDB-GENE-030131-3729	Length:	590	Species:	Danio rerio

Alignment Length:	601	Identity:	253/601 - (42%)
Similarity:	367/601 - (61%)	Gaps:	51/601 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TGHISKSKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVP 68
            ||:.....||           :||..|:.|::|||:|.|..:.|.|||||||||||||||||.:|
Zfish     9 TGNQQADITP-----------EERGQWANKIEFLLTVAGAIIGLGNVWRFPYLCYKNGGGAFFIP 62

  Fly    69 YGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLR 133
            |.:.||..|||||.:|.:|||:..:|.|.||.::.|||:|:|||..||..|....|.:||||:..
Zfish    63 YVLYLVTCGIPLFVLETSLGQYTSQGGIMCWRKVCPLFEGMGYASQLIIVYGSITYIIIIAWAFL 127

  Fly   134 FFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLD 198
            :.|:||...|||.||||.|||..|.....:|:|        |:|                .|.|:
Zfish   128 YLFSSFNVELPWASCNNPWNTDTCIVLSGRNSS--------SEL----------------ASPLN 168

  Fly   199 TSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGK 263
            :|         |:..|:::..:|.|  |.|:..||.::||:||.||:|:::.||.:|||:.::||
Zfish   169 SS---------SSVMEFWHHRVLRL--SSGVEHLGTVRWDLALILLLVWILVYFCIWKGVKSTGK 222

  Fly   264 VVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVL 328
            .|:|||.|||.:|||||:||:||||:..||.||:.|:.:.:...:||:||.||:|:|.....|.|
Zfish   223 AVYFTATFPYVMLLILLLRGVTLPGALNGIYYYMYPDLTRLADPQVWMDAGTQIFYSYAICLGYL 287

  Fly   329 LAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVY 393
            .:..|||:|:||.|:|:.....:||.|||:.||.||||||:||...||.|..||..||||||:||
Zfish   288 SSLGSYNQYNNNCYRDSFYLCLLNSGTSFLGGFAIFSVLGHMAQEQGVDISLVAESGPGLVFIVY 352

  Fly   394 PAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKR---NRELFVAGLFSLY 455
            |.|:..:|.|.|||:.||:|::.|||||.|.|.|:|:|:::|.||.:.|   .||:.:.|:..:.
Zfish   353 PQAVTMLPLSQFWAVCFFIMIILLGLDSQFVGLESIMTSVTDIFPTVLRRGFRREMLLLGICLVC 417

  Fly   456 FVVGLASCTQGGFYFFHLLDRY-AAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYW 519
            :.:||...|:||.|...|.|.| .:|.::|.....:::|:.|:||.:||.|:|:||||:.|....
Zfish   418 YFMGLLMITEGGLYIIQLFDHYVCSGTTLLFLATCQSVAIGWVYGADRFYENIQDMIGYKPWPMV 482

  Fly   520 QVCWRFVAPIFLLFITVYGLIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTP 583
            :.||.:|.|...:...::.|:.|.||.:.: |:||.||..:||.:|.||:.:||...|:||....
Zfish   483 KYCWLYVTPSVCVGTFIFSLVKYSPLKFNNKYMYPWWAYGIGWFLAVSSLSLIPINMIYKLHKGK 547

  Fly   584 GSLRQRFTILTTPWRD 599
            |:..:|..:..:|..|
Zfish   548 GTFWERLQLACSPAED 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	246/574 (43%)
slc6a11a	NP_001091857.1	SLC6sbd-TauT-like	21..560	CDD:271387	246/573 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820