Protein Alignment DAT and slc6a19a.1

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001091648.1
• Gene: slc6a19a.1 / 553256
• ZFINID: ZDB-GENE-070620-2
• Length: 629
• Species: Danio rerio
• Alignment Length: 628
• Identity: 209/628 - (33%)
• Similarity: 303/628 - (48%)
• Gaps: 125/628 - (19%)

  Fly    26 ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQH 90
            ||..|..|..::|:.:||.|.|.|||||||||..:|||||::|:.|:||:.|:||.::|.|:||.
Zfish    30 ERPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGVPLLHLEFAIGQR 94

  Fly    91 NRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTP 155
            .|.|::..|..:.|...|:|.|.:|.:|.|..|||.|:||.:.:.|.|....|||:.|
Zfish    95 LRSGSVGVWRSISPYLTGVGIASMLASFIVGMYYNTIMAWVMWYLFNSLQEPLPWSQC------- 152

  Fly   156 NCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYI 220
                         ||..|.:.|.:                          |..:|:..:|| .|.
Zfish   153 -------------PVNLNRTGLVS--------------------------ECERSSPVDYF-WYR 177

  Fly   221 LELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLT 285
            ..||.|..|.|.||::|.:.||||..:...|....:||.|:||.|:.|:..||.||.|.|||.||
Zfish   178 ETLNTSTAIEDSGALQWWLVLCLLCAWTFLYICCIRGIETTGKAVYITSTLPYVVLTIFLIRALT 242

  Fly   286 LPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSF 350
            |.||..||::..||:.:.:.....|:||..||.||....||.|::::|||..|||..:||:..|.
Zfish   243 LKGSVNGIKFLFTPDVNELMNPSTWLDAGAQVLFSFSLAFGGLISFSSYNSVHNNCEQDAVTISI 307

  Fly   351 INSATSFIAGFVIFSVLGYMA-----------------------------------HTLGVRIED 380
            ||..||..:..||:|::|:.|                                   ..|.:...|
Zfish   308 INGLTSVYSATVIYSIIGFRATENYDICLDSNILSLLNAFDLPEGSITENNYTVALQQLNISRPD 372

  Fly   381 V-----------------ATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEA 428
            :                 ..||.||.|:|:..||..||.|..|:::||:||..|||.:.||..|.
Zfish   373 IIQELQLKTCDMQTLLSEGVEGTGLAFIVFTEAITKMPVSPLWSVLFFIMLFCLGLSTMFGNIEG 437

  Fly   429 IITALSD------EFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAV 487
            ::..|.|      .:||     |:|......:.|:..|......|.|:..|.|.:|....:||..
Zfish   438 VVVPLQDLNLLPKRWPK-----EVFTGLTCVVSFLTALVFVQSSGNYWLALFDGFAGSIPLLVIA 497

  Fly   488 FFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIG--YEPLTY--- 547
            ..|.|||.::||.:||:|||:.|:|..|..:||:.|||::|:.||.|.::..|.  .:.|||
Zfish   498 LCELIAVVYVYGIDRFNEDIKFMVGHKPNIFWQISWRFLSPVILLVILIFYFITTVSKQLTYNVW 562

  Fly   548 ----ADYV------YPSWANALGWCIAGSSVVMIPAVAIFKLL 580
                ||:.      ||:|.:.:.:.:||...:.||.|||.:.|
Zfish   563 DPQSADFPTLKEVDYPNWISVVIFVLAGVPSLCIPGVAIGRAL 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	208/627 (33%)
slc6a19a.1	NP_001091648.1	SLC5-6-like_sbd	31..611	CDD:294310	208/627 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810