Protein Alignment DAT and SLC6A15

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_877499.1
• Gene: SLC6A15 / 55117
• HGNCID: 13621
• Length: 730
• Species: Homo sapiens
• Alignment Length: 690
• Identity: 230/690 - (33%)
• Similarity: 348/690 - (50%)
• Gaps: 150/690 - (21%)

  Fly    19 DNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYM 83
            :.:.:.|||..|:.|:.::|:.:||:|.|.|||||||||.||||||:|:||.|:|:|.|||||::
Human    53 EGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFL 117

  Fly    84 ELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSC 148
            ||::||..|:|:|..|..:.|...|||:|..::.::|..||||||.|||.:|..||...|||..|
Human   118 ELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQC 182

  Fly   149 NNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAAS 213
                                |::.|.|..:.                        ..|..||:|:
Human   183 --------------------PLVKNASHTFV------------------------EPECEQSSAT 203

  Fly   214 EYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLI 278
            .|: .|...||.|..|.:.|.:.|.|.:|||..:::...::.|||.:|||:::|::||||.||:.
Human   204 TYY-WYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLIC 267

  Fly   279 LLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYK 343
            .|||...|.||..||::..||....:.:.:||.:|||||||:||.|||.::|::||||..||.:.
Human   268 FLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHF 332

  Fly   344 DALLTSFINSATSFIAGFVIFSVLGYMAHTLG--------------------------------- 375
            ||:|.||||..||.:|..|:|:|||:.|:.:.
Human   333 DAVLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLST 397

  Fly   376 VRIEDV-------------------------------ATEGPGLVFVVYPAAIATMPASTFWALI 409
            |..||.                               |.:|.||.|:.:..|:...|||.||:::
Human   398 VTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVM 462

  Fly   410 FFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLL 474
            ||:||:.|||.|.||..|.|:|.:.|.|   |..:|:.......|.|.:||....:.|.||..:.
Human   463 FFLMLVNLGLGSMFGTIEGIVTPIVDTF---KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMF 524

  Fly   475 DRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGL 539
            |.|:|...:|:.|..|.|||.::||.::|.||::||:||.|.||:...|::::|:.||.:.:..:
Human   525 DDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASV 589

  Fly   540 I--GYEPLTYADYV----------YPSWANALGWCIAGSSVVMIPAVAIFKLLSTP-GSLRQRFT 591
            :  |..|..|..::          ||:|           .:|:..::.:|.:|..| ..:.:||.
Human   590 VNMGLSPPGYNAWIEDKASEEFLSYPTW-----------GLVVCVSLVVFAILPVPVVFIVRRFN 643

  Fly   592 ILTTPWRDQQSMAMVLNGVTTEVTVVRLTDTETAKEPVDV 631
            ::     |..|      |....||..|   ....||||::
Human   644 LI-----DDSS------GNLASVTYKR---GRVLKEPVNL 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	218/646 (34%)
SLC6A15	NP_877499.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	41..60		0/6 (0%)
		SLC6sbd_SBAT1	61..640	CDD:212091	216/637 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820