DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and Slc6a8

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_059044.1	Gene:	Slc6a8 / 50690	RGDID:	619711	Length:	635	Species:	Rattus norvegicus

Alignment Length:	635	Identity:	264/635 - (41%)
Similarity:	385/635 - (60%)	Gaps:	45/635 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PTGHISKSKTPTPHDNDNNSIS-DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFL 66
            |.|..||...|......::.:: ..||||:.::||::|.:||||.|.|||||||||||||||.||
  Rat    27 PDGAPSKGDGPAGLGAPSSRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFL 91

  Fly    67 VPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWS 131
            :||.::.:|||||:|::|::|||..:.|:|..| .:.|||||:|||.::|.||.:.||.:::||.
  Rat    92 IPYVLIALVGGIPIFFLEISLGQFMKAGSINVW-NICPLFKGLGYASMVIVFYCNTYYIMVLAWG 155

  Fly   132 LRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSS 196
            ..:...|||.:|||.:|.:.||||:|                         ..:..:|...| :|
  Rat   156 FYYLVKSFTTTLPWATCGHTWNTPDC-------------------------VEIFRHEDCAN-AS 194

  Fly   197 LDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTS 261
            |.......:...:|...|::...:|.|  |.|:...||:.|::.||||..:::.||.:|||:.::
  Rat   195 LANLTCDQLADRRSPVIEFWENKVLRL--STGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKST 257

  Fly   262 GKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFG 326
            ||:|:|||.|||.||::||:||:.|||:..||.|||.|::|.:...:||:||.||:|||...|.|
  Rat   258 GKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLG 322

  Fly   327 VLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFV 391
            .|.|..|||:::||.||||::.:.|||.|||.||||:||:||:||...||.|..||..||||.|:
  Rat   323 ALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFI 387

  Fly   392 VYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPK---IKRNRELFVAGLFS 453
            .||.|:..||.:..||.:||.|||.|||||.|.|.|..||.|.|..|.   .:..||:.||...:
  Rat   388 AYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCA 452

  Fly   454 LYFVVGLASCTQGGFYFFHLLDRY-AAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGR 517
            |.||:.|:..|.||.|.|.|.|.| |:|.::|...|:|.:.|:|:||.:||.:||..|||:.|..
  Rat   453 LCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCP 517

  Fly   518 YWQVCWRFVAPIFLLFITVYGLIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLS 581
            :.:.||.|..|:..:.|.::.::.|:||.|.: ||||.|..|:||..|.||::.:|...:..||.
  Rat   518 WMKWCWSFFTPLVCMGIFIFNVVYYKPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLR 582

  Fly   582 TPGSLRQRFTILTTP-W----RDQQSMAMVLNGVTTEVTVVRLTDTETAK 626
            ..|::.:|:..||.| |    .:.::....:.|:||...|     :|::|
  Rat   583 AKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPV-----SESSK 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	252/575 (44%)
Slc6a8	NP_059044.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		5/19 (26%)
Slc6a8	NP_059044.1	SLC6sbd_CT1	52..621	CDD:271397	256/597 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930