Protein Alignment DAT and Slc6a12

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_059031.1
• Gene: Slc6a12 / 50676
• RGDID: 620255
• Length: 628
• Species: Rattus norvegicus
• Alignment Length: 583
• Identity: 261/583 - (44%)
• Similarity: 368/583 - (63%)
• Gaps: 41/583 - (7%)

  Fly    19 DNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYM 83
            |.:.:.| |..|:.|::|:|||.|..:.|.|||||||||||||||||.:||.|.....|||:|::
  Rat    43 DKDQVKD-RGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFL 106

  Fly    84 ELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSC 148
            |:||||::.:|::|.|.::.||.:|||.|.|:|..|::.||.:|:||:|.:.|:|||..||||:|
  Rat   107 EVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTC 171

  Fly   149 NNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAAS 213
            .|.|||.:|..|.           |||                      .|.|..:.|.|.|...
  Rat   172 TNSWNTEHCVDFL-----------NYS----------------------STRAASYSENFTSPVM 203

  Fly   214 EYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLI 278
            |::.|.:|.:  :.||||||:::|::|||||:.::||||.:|||:.::||||:|||.|||.:|:|
  Rat   204 EFWERRVLGI--TSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLII 266

  Fly   279 LLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYK 343
            |||||:||||::.||.:||.|:...:...:||:||.||:|||.....|.|.|..||||||||.|:
  Rat   267 LLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYR 331

  Fly   344 DALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWAL 408
            |::...|:||||||:||||:||:||:||...||.|.:||..||||.|:.:|.|:..||.|..|:.
  Rat   332 DSIALCFLNSATSFVAGFVVFSILGFMAQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSC 396

  Fly   409 IFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKR---NRELFVAGLFSLYFVVGLASCTQGGFYF 470
            :||:|||.|||||.|...|.::||..|.||:..|   .|||.:..:..:.:::||...|:||.|.
  Rat   397 LFFLMLLFLGLDSQFVCMECLVTASMDMFPQQLRKRGRRELLILAVAIVCYLMGLLLVTEGGMYI 461

  Fly   471 FHLLDRYA-AGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFI 534
            |.|.|.|| :|..:|....||.|.:.|:||.:||.:::.||||:.|....::.|.|:.|...|..
  Rat   462 FQLFDYYASSGICLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLAT 526

  Fly   535 TVYGLIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTP 596
            ..:.|..|.||.|.: |:||||..::||.:|.||:..:|...|..||.|.||.::|...|.||
  Rat   527 FFFSLSKYTPLKYNNVYIYPSWGYSIGWLLAFSSMACVPLFIIITLLKTQGSFKKRLQRLITP 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	259/575 (45%)
Slc6a12	NP_059031.1	SLC5-6-like_sbd	49..589	CDD:444915	258/575 (45%)