Protein Alignment DAT and slc6a9

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_005163551.1
• Gene: slc6a9 / 494490
• ZFINID: ZDB-GENE-050105-3
• Length: 653
• Species: Danio rerio
• Alignment Length: 575
• Identity: 246/575 - (42%)
• Similarity: 365/575 - (63%)
• Gaps: 31/575 - (5%)

  Fly    15 PHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIP 79
            |...|.||   .|..|..:::|:|:.:|:||.|.||||||||||:||||||:.||.||||..|||
Zfish    22 PVKRDENS---RRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIP 83

  Fly    80 LFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLP 144
            ||::||:.||....|.:..| ::.|:|||:||.:::::.|:..||||:|..:..:||.|.||.||
Zfish    84 LFFLELSFGQFTSLGCLGVW-KVSPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFMSMTNLLP 147

  Fly   145 WTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQ 209
            ||.|||.||||:|....|.:.:                     |.|:.|.|::.:.....|...:
Zfish   148 WTYCNNPWNTPDCSGVVSTHRA---------------------NATFANMSAVVSGVTEIVNRTK 191

  Fly   210 --SAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFP 272
              |.:.||:..|:  ||.|:||.:.|.::..:..||.:.:.:.:..|.:|:.:|||||:|||.||
Zfish   192 RTSPSEEYWRNYV--LNISDGIGNFGEVRLPILGCLAVSWFVVFLCLIRGVKSSGKVVYFTATFP 254

  Fly   273 YAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKY 337
            |.||.||.|||:||.|:..||:|||||.:..|..|:||.|||:|:|:|||..:|.|:..|||||:
Zfish   255 YVVLTILFIRGITLDGAISGIKYYLTPQWQKILDAKVWGDAASQIFYSLGCAWGGLITMASYNKF 319

  Fly   338 HNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPA 402
            |||.::|:::.|..|..||..|||||||:||:|||.|||.:.:||..||||.||.||.|:..:|.
Zfish   320 HNNCFRDSIIISVTNCGTSVYAGFVIFSILGFMAHHLGVDVSEVADHGPGLAFVAYPEALTLLPI 384

  Fly   403 STFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPK--IKRNRELFVAGLFSLYFVVGLASCTQ 465
            |..|:|:||.||:.|||.:.|...|.::||:.||...  |.:|:.....|:..:.|::|:...||
Zfish   385 SPLWSLLFFFMLILLGLGTQFCLLETLVTAVVDEIGTDWIIKNKTYVTLGVAIIGFLLGVPLTTQ 449

  Fly   466 GGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIF 530
            .|.|:..|:|.|||.:|:::......|.:.::||...:.:|:..|:||||..::::|||:|:|..
Zfish   450 AGIYWLLLMDNYAASFSLVIISCIMCICIMYVYGHKNYFKDVEMMLGFPPPIFFRICWRYVSPFI 514

  Fly   531 LLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGS 585
            :.||.::.:|.|:|:||.|||||.|:..:|:.:|.|||:.||..|:||:..:.||
Zfish   515 ITFILIFTVIQYKPITYNDYVYPGWSLVIGFAMALSSVICIPIYALFKIAMSEGS 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	242/563 (43%)
slc6a9	XP_005163551.1	SLC6sbd_GlyT1	15..598	CDD:212067	246/575 (43%)