DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and slc6a5

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001009557.1	Gene:	slc6a5 / 494450	ZFINID:	ZDB-GENE-050105-2	Length:	786	Species:	Danio rerio

Alignment Length:	606	Identity:	273/606 - (45%)
Similarity:	384/606 - (63%)	Gaps:	47/606 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DNDNNSISDE---RETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGI 78
            |:|::...||   |..||.|:||:||::|:||.|.||||||||.::|||||||:||.|||.:.||
Zfish   164 DDDDDDGGDENKARGNWSNKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLIMLGLAGI 228

  Fly    79 PLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSL 143
            |:|.:|::|||...:|.::.| :.:|..:|.|.|:::|:..:..|||:|:.|:|.:.|||...:|
Zfish   229 PIFLLEVSLGQFASQGPVSVW-KAIPALQGCGIAMLIISVLIAIYYNIIMCWTLYYLFASLKETL 292

  Fly   144 PWTSCNNIWNTPNCRP----------FESQNASRVP---------VIGNYSDLYAMGNQSLLYNE 189
            ||.:|.|.|||..|:.          ...:|.:.:.         |:||.|.|..:    .:.|:
Zfish   293 PWATCKNEWNTVECKDKDMLLLDTCILRDRNITSIKNTTFCLSANVVGNLSKLLNV----TVDNK 353

  Fly   190 TYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSL 254
            ||:                 |.:.|||...:|.:  |:||...|.|:|.:|.||.:.:||.|.||
Zfish   354 TYV-----------------SPSEEYFKYNVLHI--SKGIEYPGDIRWPLAACLFLAWLIVYASL 399

  Fly   255 WKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFF 319
            .|||.:|||||:|||.|||.||:||||||:||||:..||.|::||.:..:..|:||.|||||:||
Zfish   400 AKGIKSSGKVVYFTATFPYVVLVILLIRGVTLPGAGSGILYFITPKWEKLNDAKVWKDAATQIFF 464

  Fly   320 SLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATE 384
            ||...:|.|:..:||||:|||.|:|.|:.:..|||||..||||||||:|:|||.|.|.||.||.|
Zfish   465 SLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAHELKVPIESVADE 529

  Fly   385 GPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPK-IKRNRELFV 448
            |||:.|||||.|:..:|.|.|||:|||:||||||||:.|...|.|:|::|||||| :::::..|.
Zfish   530 GPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSVSDEFPKYLRKHKPQFT 594

  Fly   449 AGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGF 513
            ......:||:|....|:.|.|...|:|.:||.||:::...||.:.:|:|||..||.|||..||||
Zfish   595 LVCCLSFFVLGFPMITESGMYMLQLVDTFAASYSLVIIAIFELVGISYIYGLQRFCEDIEMMIGF 659

  Fly   514 PPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFK 578
            .|.::|:|||.||.|..|.||....|..::.:||.||.||:|:..|||.:...||:.||.:...|
Zfish   660 QPNKFWRVCWAFVTPTILTFILALSLYQWKVMTYEDYTYPNWSMVLGWLMVICSVIWIPIMFAIK 724

  Fly   579 LLSTPGSLRQRFTILTTPWRD 599
            :...||||.:|..::.:|..|
Zfish   725 MHLAPGSLIERLKLVCSPQPD 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	267/589 (45%)
slc6a5	NP_001009557.1	SLC5-6-like_sbd	177..775	CDD:294310	269/593 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820