Protein Alignment DAT and slc6a5

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001009557.1
• Gene: slc6a5 / 494450
• ZFINID: ZDB-GENE-050105-2
• Length: 786
• Species: Danio rerio
• Alignment Length: 606
• Identity: 273/606 - (45%)
• Similarity: 384/606 - (63%)
• Gaps: 47/606 - (7%)

  Fly    17 DNDNNSISDE---RETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGI 78
            |:|::...||   |..||.|:||:||::|:||.|.||||||||.::|||||||:||.|||.:.||
Zfish   164 DDDDDDGGDENKARGNWSNKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLIMLGLAGI 228

  Fly    79 PLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSL 143
            |:|.:|::|||...:|.::.| :.:|..:|.|.|:::|:..:..|||:|:.|:|.:.|||...:|
Zfish   229 PIFLLEVSLGQFASQGPVSVW-KAIPALQGCGIAMLIISVLIAIYYNIIMCWTLYYLFASLKETL 292

  Fly   144 PWTSCNNIWNTPNCRP----------FESQNASRVP---------VIGNYSDLYAMGNQSLLYNE 189
            ||.:|.|.|||..|:.          ...:|.:.:.         |:||.|.|..:    .:.|:
Zfish   293 PWATCKNEWNTVECKDKDMLLLDTCILRDRNITSIKNTTFCLSANVVGNLSKLLNV----TVDNK 353

  Fly   190 TYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSL 254
            ||:                 |.:.|||...:|.:  |:||...|.|:|.:|.||.:.:||.|.||
Zfish   354 TYV-----------------SPSEEYFKYNVLHI--SKGIEYPGDIRWPLAACLFLAWLIVYASL 399

  Fly   255 WKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFF 319
            .|||.:|||||:|||.|||.||:||||||:||||:..||.|::||.:..:..|:||.|||||:||
Zfish   400 AKGIKSSGKVVYFTATFPYVVLVILLIRGVTLPGAGSGILYFITPKWEKLNDAKVWKDAATQIFF 464

  Fly   320 SLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATE 384
            ||...:|.|:..:||||:|||.|:|.|:.:..|||||..||||||||:|:|||.|.|.||.||.|
Zfish   465 SLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAHELKVPIESVADE 529

  Fly   385 GPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPK-IKRNRELFV 448
            |||:.|||||.|:..:|.|.|||:|||:||||||||:.|...|.|:|::|||||| :::::..|.
Zfish   530 GPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSVSDEFPKYLRKHKPQFT 594

  Fly   449 AGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGF 513
            ......:||:|....|:.|.|...|:|.:||.||:::...||.:.:|:|||..||.|||..||||
Zfish   595 LVCCLSFFVLGFPMITESGMYMLQLVDTFAASYSLVIIAIFELVGISYIYGLQRFCEDIEMMIGF 659

  Fly   514 PPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFK 578
            .|.::|:|||.||.|..|.||....|..::.:||.||.||:|:..|||.:...||:.||.:...|
Zfish   660 QPNKFWRVCWAFVTPTILTFILALSLYQWKVMTYEDYTYPNWSMVLGWLMVICSVIWIPIMFAIK 724

  Fly   579 LLSTPGSLRQRFTILTTPWRD 599
            :...||||.:|..::.:|..|
Zfish   725 MHLAPGSLIERLKLVCSPQPD 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	267/589 (45%)
slc6a5	NP_001009557.1	SLC5-6-like_sbd	177..775	CDD:444915	269/593 (45%)