DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and slc6a1b

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001007363.1	Gene:	slc6a1b / 492490	ZFINID:	ZDB-GENE-041114-57	Length:	600	Species:	Danio rerio

Alignment Length:	604	Identity:	258/604 - (42%)
Similarity:	378/604 - (62%)	Gaps:	54/604 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GHI--SKSKTPTPHDNDNNSI--------SDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYK 59
            ||:  ..::.||.:|.....:        ..:||||.||.|||||.:|:|:.|.|||||||||.|
Zfish    11 GHVLTEVNEAPTANDKPKTLVVKVQKKKELPDRETWQGKFDFLLSCVGYAIGLGNVWRFPYLCGK 75

  Fly    60 NGGGAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYY 124
            |||||||:||.:.|:..|:|||::|.||||:...|.:..| :|.|:|||:|.|..:::|:::.||
Zfish    76 NGGGAFLIPYFLTLIFAGVPLFFLETALGQYTSIGGLGVW-KLAPMFKGVGLAAAVLSFWLNIYY 139

  Fly   125 NVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNE 189
            .|||||::.:.:.|||..|||.||:|.|||..|             ..||| :..:||.:
Zfish   140 IVIIAWAIYYLYNSFTTDLPWKSCDNPWNTDKC-------------FSNYS-MANIGNMT----- 185

  Fly   190 TYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSL 254
                                ||..|::.|.:.:|  ::|:...|.|:..:|:.|.|.:::.||.:
Zfish   186 --------------------SAVVEFWERNMHQL--TDGLEKPGEIRLPLAITLAIAWVLVYFCI 228

  Fly   255 WKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFF 319
            |||:..:||||:|:|.:||.:|.||.|||:||||:..||.:|:||.||.:.::|||:|||||:||
Zfish   229 WKGVGWTGKVVYFSATYPYFMLFILFIRGVTLPGAKEGILFYVTPEFSKLKESEVWLDAATQIFF 293

  Fly   320 SLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATE 384
            |.|.|.|.|:|..|||.::||||||:::...|||.||..|||||||::|:|||.....|.|||..
Zfish   294 SYGLGLGSLIALGSYNPFNNNVYKDSIIVCCINSFTSMFAGFVIFSIVGFMAHITKRPIADVAAS 358

  Fly   385 GPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPK-IKRNRELFV 448
            ||||.|:.||.|:..:|.|..||::||.|||.||:||.|...|..||||.||||: ::..||:|:
Zfish   359 GPGLAFLAYPEAVTQLPISPLWAVLFFSMLLMLGIDSQFCTVEGFITALVDEFPRALRGRREIFI 423

  Fly   449 AGLFSLYFVVGLASCTQGGFYFFHLLDRY-AAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIG 512
            |.:..:.:::||::.||||.|.|.|.|.| |:|..:|..||||.:::||.||.|:|..::.:|||
Zfish   424 AVVCLVSYLIGLSNITQGGLYVFKLFDYYSASGMCLLFLVFFECVSISWFYGVNKFYGNLEEMIG 488

  Fly   513 FPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIF 577
            :.|..:|::||....|:.:..:.::..:...|||..:||:|.|...:|||:|.||:|:||....:
Zfish   489 YKPCIWWKLCWVVFTPLIVAGVFLFSAVQMVPLTLNNYVFPKWGQGVGWCMALSSMVLIPGYMGY 553

  Fly   578 KLLSTPGSLRQRFTILTTP 596
            ..|:..||.::|..|:..|
Zfish   554 MFLTLKGSYKERLRIMIQP 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	253/572 (44%)
slc6a1b	NP_001007363.1	SLC5-6-like_sbd	2..600	CDD:294310	258/604 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820