Protein Alignment DAT and SLC6A17

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001010898.1
• Gene: SLC6A17 / 388662
• HGNCID: 31399
• Length: 727
• Species: Homo sapiens
• Alignment Length: 637
• Identity: 224/637 - (35%)
• Similarity: 333/637 - (52%)
• Gaps: 127/637 - (19%)

  Fly    24 SDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALG 88
            :::|..|:.|:.::|:.|||:|.|.|:|||||||.||||||:||||.::|::.|||||::|||:|
Human    57 AEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVG 121

  Fly    89 QHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWN 153
            |..|:|:|..|..:.|...|||::..::..:|..||||||.||:.:||.||...|||:.|
Human   122 QRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSEC----- 181

  Fly   154 TPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNR 218
                           ||:                    .|||    .||...|..:|:|:.|| .
Human   182 ---------------PVV--------------------RNGS----VAVVEAECEKSSATTYF-W 206

  Fly   219 YILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRG 283
            |...|:.|:.|.:.|.:.|.|.||||:.:.|...::.|||.:||||::|::||||.||...|:||
Human   207 YREALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRG 271

  Fly   284 LTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLT 348
            |.|.|:..||.:..||....:...:||.:|||||||:||.|||.::|::||||..||.:.||.|.
Human   272 LLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALV 336

  Fly   349 SFINSATSFIAGFVIFSVLGYMAHTLGVR--IE-------------------------------- 379
            ||||..||.:|..|:|:|||:.|:.:..:  :|
Human   337 SFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKD 401

  Fly   380 ------------------------------DVATEGPGLVFVVYPAAIATMPASTFWALIFFMML 414
                                          |.:.:|.||.|:.:..|:...|||.||:::||:||
Human   402 YMEMYNVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML 466

  Fly   415 LTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAA 479
            :.|||.|..|....|.|.:.|.|   |..:|:|..|.....|:|||....:.|.||..:.|.|:|
Human   467 INLGLGSMIGTMAGITTPIIDTF---KVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSA 528

  Fly   480 GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLI--GY 542
            ...:.:.|..|.|||:|||||.:|.:::.:|:||.|.|::...|:||:|:.:..:|...:|  |.
Human   529 TLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGV 593

  Fly   543 EPLTYADYV----------YPSWANALGWCIAGSSVVMIPAVAI---FKLLS 581
            .|..|:.::          :|:||.||...:...:.:.||.|.:   |.|||
Human   594 TPPGYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLRHFHLLS 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	224/634 (35%)
SLC6A17	NP_001010898.1	SLC6sbd_NTT4	60..648	CDD:271403	224/634 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..727

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820