Protein Alignment DAT and Slc6a16

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001311464.1
• Gene: Slc6a16 / 381884
• MGIID: 2685930
• Length: 742
• Species: Mus musculus
• Alignment Length: 718
• Identity: 180/718 - (25%)
• Similarity: 301/718 - (41%)
• Gaps: 159/718 - (22%)

  Fly     1 MSPTGHISKSKTPTPHDNDN----NSISDE-------RETWSGKVDFLLSVIGFAVDLANVWRFP 54
            :.|...:::..|.|..:.::    |.:|.|       |:.|:.||:::|:::.:.:..:.|.||.
Mouse    88 LQPKPSVTELATVTTLEQESSELVNRMSRESSEGYPPRQLWASKVEYMLAIMSYLLMPSGVLRFA 152

  Fly    55 YLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFY 119
            ......|..:|.:.|.:||:..||||.::|:|:||..::.:...|..|.|.|.|:||::|::.|.
Mouse   153 SGWVHKGSCSFFIAYILMLLGIGIPLLFLEMAVGQRAQQSSADMWKNLSPWFGGVGYSMVMVCFI 217

  Fly   120 VDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQS 184
            .:.|.||..:|.|.:....|...:||..|          |.:
Mouse   218 TNTYLNVFNSWILFYMSHIFYFVVPWDQC----------PLQ----------------------- 249

  Fly   185 LLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVY-L 248
                   .|.|:.|.      |..|:.:..|| .|...|..|:.|.|.|...:.:.:.|.:.: |
Mouse   250 -------RNSSNFDP------ECEQATSYTYF-WYRKTLKASDRIEDGGQPSFSLGMSLFLSFCL 300

  Fly   249 ICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDA 313
            ||.| |..||.:.|||::...|.||::::..|||.|::.|:..|:::.|....::|....:|..|
Mouse   301 ICAF-LVNGIKSIGKVLFVLLLVPYSIIVCFLIRTLSMDGAEYGLKHLLILKVASISDLTIWCHA 364

  Fly   314 ATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTL---- 374
            ..||.|.:|.|||.:::.||:....||...||.|.:.....|..:....:.|:||:.|.|.
Mouse   365 GIQVLFDIGLGFGPIVSLASHVPDFNNCMADAFLMALFKIITLLMTTPFLLSILGFWATTTTHHC 429

  Fly   375 --------------GVRIEDV-------------------------------------------A 382
                          |:...|.                                           .
Mouse   430 CKKNQETLLRLVAQGILPPDAQPPDLSGNPTSNYNSWLSSLPPPLRSAVLSVVPECSVQKQFLKI 494

  Fly   383 TEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELF 447
            .:.|..:|:::...|:.:|.|.||.::||::||||||.|:.......:..|.|.||..:|...|.
Mouse   495 KDNPRFLFLIFTEVISLLPGSGFWIVLFFLLLLTLGLCSNLMFMLGNVLTLQDTFPFCRRQPRLL 559

  Fly   448 VAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIG 512
            :..:....|:.||......|.|:|.||........:::.:..|.:||:|.||.:||..|:..::|
Mouse   560 IVCVSMAMFLCGLIFIQPSGIYYFSLLSECWVAVPVIIIIICENLAVAWAYGADRFLADMVALLG 624

  Fly   513 FP--PGRYWQVCWRFVAPIFLL----FITVYGLIGYEPLTYADY----------VYPSWANALGW 561
            .|  .|..|  .|.:::|:.:|    .:.||.:.|  ||.|..:          |:|.|:..|
Mouse   625 RPIFSGCGW--LWCYISPMVVLGLLTSVFVYLVKG--PLVYFAWDSSTSKEVVRVFPEWSKIL-- 683

  Fly   562 CIAGSSV-VMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQQSMAMVLNG----VTTEVTVVRLTD 621
             |||.:| |::|..|.|....|.|          .|:|...|..:.|..    .|.|.:...|.|
Mouse   684 -IAGLTVFVLMPIPAYFVYCLTLG----------IPFRSTPSSKLPLGSGQLQSTKEASKDILQD 737

  Fly   622 TET 624
            .:|
Mouse   738 YKT 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	165/648 (25%)
Slc6a16	NP_001311464.1	SLC5-6-like_sbd	125..694	CDD:294310	160/623 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920