Protein Alignment DAT and SerT

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001369117.1
• Gene: SerT / 37895
• FlyBaseID: FBgn0010414
• Length: 768
• Species: Drosophila melanogaster
• Alignment Length: 585
• Identity: 290/585 - (49%)
• Similarity: 391/585 - (66%)
• Gaps: 44/585 - (7%)

  Fly    27 RETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHN 91
            ||||..|.:|||:||||||||.|||||||:||:||||||||||.:.|:.||:|||||||||||.:
  Fly    74 RETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFH 138

  Fly    92 RKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPN 156
            |.|.::.|.|:.|..||:|||:.||..|:..|||.||.|::.:.|||||:.||||||:|.|||.|
  Fly   139 RCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTEN 203

  Fly   157 CRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYIL 221
            |....|:|.:.:..                                       |.|.|:|.|.:|
  Fly   204 CMQVTSENFTELAT---------------------------------------SPAKEFFERKVL 229

  Fly   222 ELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTL 286
            |..:..|:..:|.:|..:|||:..|:::.|||||||:.::|||||.|||.||.||:|||:||::|
  Fly   230 ESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSL 294

  Fly   287 PGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFI 351
            ||:..||:|||||.:..:..::||:|||:|:|||||||||.|||.:||||::||.|:|||:||.|
  Fly   295 PGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSI 359

  Fly   352 NSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLT 416
            |..|||:|||||||||||||:.....|:.|..|||||||:|||.|||||..|.||::|||:||:|
  Fly   360 NCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIFFLMLIT 424

  Fly   417 LGLDSSFGGSEAIITALSDEFPK-IKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAG 480
            |||||:|||.||:||||.||:|: |.|.|||||..|.:..|:..|.:.|.||....:.|:.|..|
  Fly   425 LGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVYGPG 489

  Fly   481 YSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPL 545
            .:||..||.||..|.|.||.:|||.|:..|:|..||.:|::||.:::|:|||.|.::.::||:.:
  Fly   490 LAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEM 554

  Fly   546 TYADYVYPSWANALGWCIAGSSVVMIPAVAIFK-LLSTPGSLRQRFTILTTPWRDQQSMAMVLNG 609
            ...:|.||.|:..:||.:..|||:.||...|:| ..::.|..|||   |...::.:.:...|:.|
  Fly   555 LGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCRQR---LQESFQPEDNCGSVVPG 616

  Fly   610  609
              Fly   617  616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	288/571 (50%)
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	288/574 (50%)