DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and GlyT

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster

Alignment Length:	657	Identity:	270/657 - (41%)
Similarity:	390/657 - (59%)	Gaps:	73/657 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQH 90
            ||.||:|:.|||||::|::|.|.||||||||||.|||||||:|:.||||:.|:||.:|||:.||:
  Fly    56 ERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQY 120

  Fly    91 NRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTP 155
            ...|.:..:.|..|||:|:|..::|::..|..|||:||||::.:.||||...|||.:|...|:|.
  Fly   121 AALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTK 185

  Fly   156 NCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYM-----NGSS-----LDTSAVGHVEGFQS 210
            .|                :|  ||..:|....|.||.     |.:|     :.|.|:|.::  :.
  Fly   186 YC----------------FS--YAQADQCEATNGTYYLRTCHNATSAAENNITTLALGALK--RP 230

  Fly   211 AASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAV 275
            .|.||||.::|.|  |:||.:.|:||..:|.||.:.:.|.:..|.||:.:|||||:|||||||.|
  Fly   231 PAEEYFNNFVLGL--SKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVV 293

  Fly   276 LLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNN 340
            |:||.:||:||||:..||.:||||::..:..|:||.|||.|:||:|.|.:|.|:..:||||:.||
  Fly   294 LVILFVRGVTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNN 358

  Fly   341 VYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTF 405
            .|||:|:.:|.|.||||.||.||||::|::||.|.|.:|.|..:|.||.|:|||..:..:|.|..
  Fly   359 CYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPV 423

  Fly   406 WALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYF 470
            ||::||:|||||||||.|...|.:.||:.|.||.:::.:...|..:....::.||...|..|.|:
  Fly   424 WAVLFFVMLLTLGLDSQFALMETVTTAILDRFPNLRQYKIWVVLSVAIFGYIGGLGFTTNSGMYW 488

  Fly   471 FHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIG-------FPPGRYWQVCWRFVAP 528
            ..|:|:|||.:|:|:....|.|.::||||:.||..||:.|||       |    :|.:.||::.|
  Fly   489 LQLMDKYAANWSVLLIAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNF----FWGIMWRYITP 549

  Fly   529 IFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSL--RQRFT 591
            ..||||..:..:.|:|..|..||||.||:|:||.:....|::|..||..::...|.||  |.|..
  Fly   550 ATLLFILFFNWVEYKPAKYGHYVYPMWADAVGWIVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIK 614

  Fly   592 ILTTP---W----------RDQQSMAMVLNGVTTEVTVVRLTDTETAKE-------------PVD 630
            .|..|   |          ..::..:...:|||.  |.:.:.:..:.|:             .||
  Fly   615 HLLQPTAEWGPAGRPCVNLHAERYQSQNYDGVTN--TKILIEEEASPKQAANKKDRQLTLDVDVD 677

  Fly   631 VXVRPVA 637
            |...|:|
  Fly   678 VECLPLA 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	258/591 (44%)
GlyT	NP_611836.2	SNF	57..603	CDD:249680	251/571 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16523at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920