Protein Alignment DAT and CG43066

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Alignment Length: 661
• Identity: 231/661 - (34%)
• Similarity: 327/661 - (49%)
• Gaps: 136/661 - (20%)

  Fly    15 PHDNDNNSI-----SDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLV 74
            |..|...|:     ..||..||||:.|.||:||::|.|.|:|||||||.:|||||||:|:.:||:
  Fly    38 PQRNSVQSVDIPGNEPERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLI 102

  Fly    75 VGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASF 139
            :.|||||.:||.:||..|.||:..|..:.|...|||.:..::..:|..||||||.|...:.|.||
  Fly   103 LEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSF 167

  Fly   140 TNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGH 204
            ...|||:||.                                          :||:..:..
  Fly   168 RYPLPWSSCP------------------------------------------LNGTGFELE---- 186

  Fly   205 VEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTA 269
             |..:|:.:.|| .|...|:.:..:.:.|.:||.:.|||::.:.|.:|.:.|||.:|||||:||:
  Fly   187 -ECAKSSETTYF-WYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTS 249

  Fly   270 LFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASY 334
            ||||.||.|..|||:||.|:..|:.:..||....:.:..||:|||||||:|.|..||.|:|:.||
  Fly   250 LFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSY 314

  Fly   335 NKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGY------------------------------ 369
            |...||..:|.||.|..|:.|:..|..|||::||:
  Fly   315 NTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLGLNDTQG 379

  Fly   370 ----------------------MAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFM 412
                                  :||.|     |.|.||.||.|:|:..||..:|.:.|||::||.
  Fly   380 YEQAMSLLNGTELLRLQLSECSLAHEL-----DNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFT 439

  Fly   413 MLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLY-FVVGLASCTQGGFYFFHLLDR 476
            |||:|||.|..|..|.::..|.| ...|||.::..|.|:..|: |:||...||..|.|:..:.|.
  Fly   440 MLLSLGLGSQIGILEGMLCTLFD-IDIIKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDS 503

  Fly   477 YAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITV----- 536
            :|....::|....|.|||.:|||..||:|||..|.|:.||||||..||::.|:.::.|.|
  Fly   504 FAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVVF 568

  Fly   537 -------YGLIGYEPLTYADYVYPSWAN--ALGWCIAGSSVVMIPAVAI---FKLLST-----PG 584
                   ||....:........||:|..  ||...:||  |:.:|.|.:   |:.|..     .|
  Fly   569 MVIRNPTYGAWNADLGMIEQKSYPNWVMGIALSMILAG--VLPMPIVFLMRSFQCLKVDLDIHQG 631

  Fly   585 SLRQRFTILTT 595
            |:|:..|..:|
  Fly   632 SIRRNETTAST 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	227/644 (35%)
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	220/617 (36%)