DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and slc6a22.1

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_005166076.1	Gene:	slc6a22.1 / 368923	ZFINID:	ZDB-GENE-030616-629	Length:	584	Species:	Danio rerio

Alignment Length:	603	Identity:	251/603 - (41%)
Similarity:	369/603 - (61%)	Gaps:	54/603 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 HDND-------NNSISDE-------RETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFL 66
            ||.|       :::.|:|       |..||.||:|:|:|.|..:.|.|||||||||||||||.|.
Zfish     5 HDPDLQFKLAYSDAQSNETGLKTQIRGQWSSKVEFILAVAGQIIGLGNVWRFPYLCYKNGGGVFF 69

  Fly    67 VPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWS 131
            :||.:.|...|||||.||.||||:..:|::|||.::.|||:|:||...::..|...||.:|:||:
Zfish    70 IPYVVFLFACGIPLFLMETALGQYTSQGSVTCWRKICPLFEGLGYGSQVVVLYSSAYYIIILAWA 134

  Fly   132 LRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSS 196
            ..:.|:||:..|||.||.|.||:.||..|:....::                    |.::|..:|
Zfish   135 FFYLFSSFSGELPWASCRNWWNSENCVEFDRMQGAK--------------------NLSFMANAS 179

  Fly   197 LDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTS 261
                         |...|::.|.:|.:..|  :::||:::|::|||||:.::||||.:|||:.::
Zfish   180 -------------SPVKEFWERRVLNITGS--VNELGSVRWELALCLLLAWVICYFCVWKGVKST 229

  Fly   262 GKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFG 326
            ||||:|||.|||.:|::||||||||||:..||.:||.||.:.:...:||:||.||:|:|.....|
Zfish   230 GKVVYFTATFPYVMLMVLLIRGLTLPGAIDGITFYLYPNPARLADPQVWMDAGTQIFYSYALCIG 294

  Fly   327 VLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFV 391
            .|.|..|||||:||.|||.:....:||.|||:|||.||||||:||...||.|..||..||||.|:
Zfish   295 CLTALGSYNKYNNNCYKDCVYLCLLNSGTSFVAGFAIFSVLGFMALEQGVDISVVAESGPGLAFI 359

  Fly   392 VYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKI---KRNRELFVAGLFS 453
            .||.|:|.||.:..|::.||:|::.|||||.|.|.|:::||::|..|..   ...|:||:..:..
Zfish   360 AYPRAVAMMPMAQLWSICFFLMIILLGLDSEFVGLESLMTAITDMNPNFFLQGHRRKLFLLVICI 424

  Fly   454 LYFVVGLASCTQGGFYFFHLLDRYA-AGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGR 517
            ..|::||...|:||.|.|.|.|.|: :|.::|:....::|.:.|.||.:|..|:|.||||:.|..
Zfish   425 ACFLIGLLMVTEGGLYVFQLFDYYSCSGMTLLLFAIAQSICIGWFYGADRLYENIADMIGYHPLT 489

  Fly   518 YWQVCWRFVAPIFLLFITVYGLIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLS 581
            ..:.||:::.||..:...::.|:.:.||.:.: |.||.|..|.||....||.:::|...|:.:|.
Zfish   490 LMKYCWKYITPIVCIGTFIFSLVKFTPLKFNNTYEYPWWGYAAGWWFTLSSTLLVPIWMIYAILV 554

  Fly   582 TPGSLRQRFTILTTPWRD 599
            |||:|:||..:|.||..|
Zfish   555 TPGTLKQRLRVLCTPASD 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	244/574 (43%)
slc6a22.1	XP_005166076.1	SLC6sbd-TauT-like	30..569	CDD:271387	243/573 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820