DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and CG15279

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	597	Identity:	205/597 - (34%)
Similarity:	324/597 - (54%)	Gaps:	43/597 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SKTPTPHDNDNN----SISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYG 70
            :.:|...||.::    .:.:||.||...|:||:|.|..:|.|.||||||:....|||||||:||.
  Fly    29 TNSPALRDNSDDQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYL 93

  Fly    71 IMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFF 135
            |:|.:.|.|::|:|:.:||.:.:|::..:. |.|..||:|.......|.:..||..::|...|:|
  Fly    94 IVLFLIGKPIYYLEMVIGQFSSRGSVKVFD-LCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYF 157

  Fly   136 FASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTS 200
            ..||.|.|||::|...|.. :|       .:..|...|:|.|.:...:...|.....|...:.:|
  Fly   158 IESFRNPLPWSTCRAEWGI-HC-------INSAPDASNWSQLESNDQRPQNYTMKSQNDRVITSS 214

  Fly   201 AVGHVEGFQSAASEYFNRYIL--ELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGK 263
                        ..||.:.:|  :.|..|||   |...|::.:.|.|.:...:|.:.:|:.:|||
  Fly   215 ------------EWYFVKEVLHEKPNIEEGI---GLPNWELVIGLFIAWSCVFFIIRRGVKSSGK 264

  Fly   264 VVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVL 328
            ..:|.|||||.::.:||:|.:|||||..||.|::.|.:..|...:||..|.||.|:||...||.:
  Fly   265 ASYFLALFPYVIMGVLLVRAVTLPGSIDGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNI 329

  Fly   329 LAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGV-RIEDVATEGPGLVFVV 392
            :.|:|:||:.:||::||.:.:.:::.||.:|||.||.:||::||.:|. .|..|...|.||.|:.
  Fly   330 IMYSSFNKFGHNVHRDAAIVTGLDTMTSLLAGFTIFGILGHLAHEIGTDDIGSVVKGGAGLAFIS 394

  Fly   393 YPAAIA---TMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSL 454
            ||.|||   .:|  ..::::||:||..||:.|:...:...:||:.|.||...:.:...:..:.|
  Fly   395 YPDAIAKFKNLP--QIFSVLFFLMLFVLGIGSNIAMTSCSVTAIRDRFPNFGQWQCSLLIAVVS- 456

  Fly   455 YFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYW 519
             |.:||...|.||.|...|:|.:.|....||....|...:.|||||:|..:||..|:|...|.||
  Fly   457 -FFIGLMYITPGGQYMLTLVDFFGASMIALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYW 520

  Fly   520 QVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPG 584
            ::||..:.|:.:..|.:|....|:||||.:.|||:|:.::||.|....::.:|...|..::..||
  Fly   521 RLCWSIITPLIMTVILIYFYATYQPLTYNNIVYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPG 585

  Fly   585 -----SLRQRFT 591
                 .:|..||
  Fly   586 QTLGAKIRGAFT 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	201/576 (35%)
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	201/576 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440747
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850