Protein Alignment DAT and Ntl

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Alignment Length: 648
• Identity: 242/648 - (37%)
• Similarity: 363/648 - (56%)
• Gaps: 86/648 - (13%)

  Fly     7 ISKSKTPTPH--------DNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGG 63
            ::.::.||.:        :.|.|     |..|..|.:|:||::|:|:.:.||||||||||::||.
  Fly     1 MANNQPPTTNATRKDKRIERDEN-----RGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGA 60

  Fly    64 AFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWG--RLVPLFKGIGYAVVLIAFYVDFYYNV 126
            |||:||.:|:::.||||||||:.:||.:..|   |.|  |:.||.||.|.|.|::..|...||:|
  Fly    61 AFLIPYLLMVILAGIPLFYMEILIGQFSSTG---CTGMFRMTPLLKGTGIAQVVVNAYCVCYYSV 122

  Fly   127 IIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETY 191
            ||::.:|..|..|...:||..|:|.|||.:|              ...||   ||.|
  Fly   123 IISYPIRMIFYCFFKKVPWEDCSNSWNTDDC--------------VTASD---MGKQ-------- 162

  Fly   192 MNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWK 256
             |.|.:          |:::|.|:|:..:|.:  |..|.|||.:.|:....|:|.::|.||.|.:
  Fly   163 -NSSDV----------FKTSADEFFHLEVLRI--STDISDLGGMVWEQLTALIITWIIIYFCLMR 214

  Fly   257 GISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSL 321
            ||.:.||||:||..|||.:|.||||||.||||::.||::||.|.:..:...:||.|||.|:||.:
  Fly   215 GIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFGI 279

  Fly   322 GPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGP 386
            |||:|.::..||::.:.||...|::|...||..||.:||||:|||||:::...|:.:|.|||.|.
  Fly   280 GPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESVATGGA 344

  Fly   387 GLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGL 451
            ||.||.||.|||.:|....|||:||.||..||:||.|...|||::::.||:..::.::....  |
  Fly   345 GLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWVRSHKCKLT--L 407

  Fly   452 FSLYFVVGLAS--CTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFP 514
            .|....:||:|  ||.||.:...|.|.|::..:::|....|.|.|:||||...|..|:..|:|..
  Fly   408 ISCLIFLGLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKR 472

  Fly   515 PGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPA----VA 575
            |..||::.|:.|.|:.::||.:..::....:||.:..||.||..:||....:||:.||.    :.
  Fly   473 PTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYPQWAIIIGWASCFTSVMWIPLYIFYIM 537

  Fly   576 IFKLLSTPGSLRQRFTILT-TP-----------WRDQQSMAMVLNGVTTEVTVVRLTDTETAK 626
            |.|..:...||::|...|. ||           :|.|:.|...::.          ||.|::|
  Fly   538 IRKRATLCDSLKKRLKPLDWTPADPQDRAEYEAFRRQRRMPGFMSD----------TDMESSK 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	231/589 (39%)
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:444915	228/572 (40%)