Protein Alignment DAT and SLC6A19

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001003841.1
• Gene: SLC6A19 / 340024
• HGNCID: 27960
• Length: 634
• Species: Homo sapiens
• Alignment Length: 654
• Identity: 218/654 - (33%)
• Similarity: 316/654 - (48%)
• Gaps: 139/654 - (21%)

  Fly    24 SDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALG 88
            :..|..|..|..::|:.:||.|.|.|||||||||..:|||||::|:.|:||:.||||.|:|.|:|
Human    29 ASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIG 93

  Fly    89 QHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWN 153
            |..|:|::..|..:.|..||:|.|.:|.:|.|..|||.||:|.:.:.|.||...|||:.|
Human    94 QRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDC----- 153

  Fly   154 TPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHV-EGFQSAASEYFN 217
                                                      .|:.:..|:| |..:|:..:||
Human   154 ------------------------------------------PLNENQTGYVDECARSSPVDYF- 175

  Fly   218 RYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIR 282
            .|...||.|..|.|.|:|:|.|.|||...:.:.|....:||.|:||.|:.|:..||.||.|.|||
Human   176 WYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIR 240

  Fly   283 GLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALL 347
            ||||.|:..||.:..|||.:.:.:.:.|:||..|||||....||.|::::|||..|||..||:::
Human   241 GLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVI 305

  Fly   348 TSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDV------------------------------- 381
            .|.||..||.....|::||:|:.|..   |.:|.
Human   306 VSIINGFTSVYVAIVVYSVIGFRATQ---RYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRC 367

  Fly   382 ------------------------ATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSS 422
                                    |.||.||.|:|:..||..||.|..|:::||:||..|||.|.
Human   368 NASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSM 432

  Fly   423 FGGSEAIITALSD------EFPKIKRNRELFVAGLFSL-YFVVGLASCTQGGFYFFHLLDRYAAG 480
            ||..|.::..|.|      ::||     |: :.||..| .|::|.......|.|:..|||.||..
Human   433 FGNMEGVVVPLQDLRVIPPKWPK-----EV-LTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGS 491

  Fly   481 YSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLI----- 540
            ..:|:..|.|..:|.::||.:||::||..|||..|..:|||.||.|:|:.:|.|.::..:
Human   492 IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQ 556

  Fly   541 ---------GYEPLTYADYV-YPSWANALGWCIAGSSVVMIPAVAIFKLL----STPGSLRQRFT 591
                     |||....:..: ||:|...:...:||...:.||..||:||:    ..||..:...:
Human   557 ELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVS 621

  Fly   592 ILTT 595
            .|:|
Human   622 TLST 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	218/651 (33%)
SLC6A19	NP_001003841.1	SLC5-6-like_sbd	32..612	CDD:444915	214/636 (34%)