DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and ine

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster

Alignment Length:	591	Identity:	233/591 - (39%)
Similarity:	354/591 - (59%)	Gaps:	54/591 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KTPTP--HDNDNN--SISDE-------RETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGA 64
            :||.|  .|:|::  .:|||       ::.|:.|:.|:|:.||::|.|.|||||||:|||:|||.
  Fly   310 QTPPPLGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGV 374

  Fly    65 FLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIA 129
            |||||.|:|.:..|||.:|||::||:..:|.|...|:|.|||||.|.|.|:::|.:..||:|||.
  Fly   375 FLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIG 439

  Fly   130 WSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNG 194
            :|:.:||.||...:||..|||.||||:|         .||                  ....:|.
  Fly   440 YSIYYFFTSFKTEMPWIDCNNRWNTPDC---------WVP------------------QRKGINA 477

  Fly   195 SSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGIS 259
            |:.|||        ::.:.|:|...:|::  |.|:...|.::|::..||:..:|:.||:.||.|.
  Fly   478 SAPDTS--------RTPSEEFFENKVLQI--SGGLEYPGMMRWELFACLICAWLMVYFATWKSIK 532

  Fly   260 TSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPG 324
            :|.||.:|||.||:.:::||::|.:||.|:..|::::..|.:|.:..|.||::||:|.|.|||..
  Fly   533 SSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGIT 597

  Fly   325 FGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLV 389
            ||.::::||||||:||:.:|.:..|.:|..||.:.|...||.||.:|......:.||..:|||::
  Fly   598 FGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMI 662

  Fly   390 FVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPK-IKRN---RELFVAG 450
            |||||.|:|.||.:..||::||.|||.|||:|.|...|.::|::.|.||: |||:   .|:.|..
  Fly   663 FVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLF 727

  Fly   451 LFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPP 515
            :..:..:.|:.:..|||.|:|.|:|.|||..:|:...|.:.||::|.|||.|.|::::.|.|..|
  Fly   728 VCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAP 792

  Fly   516 GRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYAD--YVYPSWANALGWCIAGSSVVMIPAVAIFK 578
            ..|.:.||..:.|..|..|.|..||.|...||.:  |.||.||..:||..|..|::.||..|:..
  Fly   793 SFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVIN 857

  Fly   579 LLSTPG 584
            .|.:.|
  Fly   858 FLRSSG 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	225/564 (40%)
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	225/564 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440817
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16523at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850