DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and Slc6a14

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_038955501.1	Gene:	Slc6a14 / 298340	RGDID:	1561810	Length:	646	Species:	Rattus norvegicus

Alignment Length:	586	Identity:	265/586 - (45%)
Similarity:	362/586 - (61%)	Gaps:	34/586 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLF 81
            :||.|   .||..||.|.|:|||::|:||.|.||||||||.|.|||||||:||.|||.:.|:|||
  Rat    35 ENDEN---QERGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLF 96

  Fly    82 YMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWT 146
            ::|.:|||....|.::.| |::|||:|:|..:|||:.:|..|||||||:||.:.||||.:.|||.
  Rat    97 FLECSLGQFASLGPVSVW-RILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYLFASFQSVLPWA 160

  Fly   147 SCNNIWNTPNCRPFESQNASRVPVI-------GNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGH 204
            :|::.|...||        ||.|::       ....|::...:.....|.|.:|||.:....
  Rat   161 NCSSSWADDNC--------SRQPIVTGCRVSTDTGGDMFMNISWVNSNNFTCLNGSEVFRPG--- 214

  Fly   205 VEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTA 269
                |..:.:|:::  :.|.||.|:.:.|.|.|.:|||||:.::|...:|:|||.:|||||:|||
  Rat   215 ----QLPSEQYWDK--VTLRRSSGMDETGVIVWYLALCLLLAWIIVGAALFKGIKSSGKVVYFTA 273

  Fly   270 LFPYAVLLILLIRGLTLPGSFLGIQYYL--TPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYA 332
            ||||.|||||||||.||.|:..||.||:  ..||:.:.:||||.|||||:|:||...:|.|:|.:
  Rat   274 LFPYVVLLILLIRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALS 338

  Fly   333 SYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAI 397
            ||||::||.|.||::....|..||..|||.|||:||:|||..|..:..|...|..|.|:.||.|:
  Rat   339 SYNKFNNNCYSDAIIVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEAL 403

  Fly   398 ATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPK-IKRNRELFVAGLFSLYFVVGLA 461
            |.:|...||:::||.|||||||||.|...|.|.|.:.|.||| :||.|.....|...:.|::||.
  Rat   404 AQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKAMKRMRVPITLGCCLILFLLGLV 468

  Fly   462 SCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRY---WQVCW 523
            ..||.|.|:.||:|.:.||:.||:|...|...:.||||.|||.|||..|||.....:   |:.||
  Rat   469 CVTQAGIYWVHLIDHFCAGWGILIAAILEIAGIIWIYGGNRFIEDIEMMIGAKRWLFWLWWRACW 533

  Fly   524 RFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQ 588
            ..:.||.|..|.|:.|:.:....|||..||.|..|||||:....::.||.:||.|::...|::.|
  Rat   534 FVITPILLSAILVWSLVKFHRPNYADIPYPDWGVALGWCMIIFCIIWIPIMAIIKIVRAEGNILQ 598

  Fly   589 R 589
            |
  Rat   599 R 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	261/576 (45%)
Slc6a14	XP_038955501.1	SLC6sbd_ATB0	42..645	CDD:271391	261/576 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820