Protein Alignment DAT and Slc6a14

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_038955501.1
• Gene: Slc6a14 / 298340
• RGDID: 1561810
• Length: 646
• Species: Rattus norvegicus
• Alignment Length: 586
• Identity: 265/586 - (45%)
• Similarity: 362/586 - (61%)
• Gaps: 34/586 - (5%)

  Fly    17 DNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLF 81
            :||.|   .||..||.|.|:|||::|:||.|.||||||||.|.|||||||:||.|||.:.|:|||
  Rat    35 ENDEN---QERGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLF 96

  Fly    82 YMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWT 146
            ::|.:|||....|.::.| |::|||:|:|..:|||:.:|..|||||||:||.:.||||.:.|||.
  Rat    97 FLECSLGQFASLGPVSVW-RILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYLFASFQSVLPWA 160

  Fly   147 SCNNIWNTPNCRPFESQNASRVPVI-------GNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGH 204
            :|::.|...||        ||.|::       ....|::...:.....|.|.:|||.:....
  Rat   161 NCSSSWADDNC--------SRQPIVTGCRVSTDTGGDMFMNISWVNSNNFTCLNGSEVFRPG--- 214

  Fly   205 VEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTA 269
                |..:.:|:::  :.|.||.|:.:.|.|.|.:|||||:.::|...:|:|||.:|||||:|||
  Rat   215 ----QLPSEQYWDK--VTLRRSSGMDETGVIVWYLALCLLLAWIIVGAALFKGIKSSGKVVYFTA 273

  Fly   270 LFPYAVLLILLIRGLTLPGSFLGIQYYL--TPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYA 332
            ||||.|||||||||.||.|:..||.||:  ..||:.:.:||||.|||||:|:||...:|.|:|.:
  Rat   274 LFPYVVLLILLIRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALS 338

  Fly   333 SYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAI 397
            ||||::||.|.||::....|..||..|||.|||:||:|||..|..:..|...|..|.|:.||.|:
  Rat   339 SYNKFNNNCYSDAIIVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEAL 403

  Fly   398 ATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPK-IKRNRELFVAGLFSLYFVVGLA 461
            |.:|...||:::||.|||||||||.|...|.|.|.:.|.||| :||.|.....|...:.|::||.
  Rat   404 AQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKAMKRMRVPITLGCCLILFLLGLV 468

  Fly   462 SCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRY---WQVCW 523
            ..||.|.|:.||:|.:.||:.||:|...|...:.||||.|||.|||..|||.....:   |:.||
  Rat   469 CVTQAGIYWVHLIDHFCAGWGILIAAILEIAGIIWIYGGNRFIEDIEMMIGAKRWLFWLWWRACW 533

  Fly   524 RFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQ 588
            ..:.||.|..|.|:.|:.:....|||..||.|..|||||:....::.||.:||.|::...|::.|
  Rat   534 FVITPILLSAILVWSLVKFHRPNYADIPYPDWGVALGWCMIIFCIIWIPIMAIIKIVRAEGNILQ 598

  Fly   589 R 589
            |
  Rat   599 R 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	261/576 (45%)
Slc6a14	XP_038955501.1	SLC6sbd_ATB0	42..645	CDD:271391	261/576 (45%)