Protein Alignment DAT and Slc6a6

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_008761345.1
• Gene: Slc6a6 / 29464
• RGDID: 61912
• Length: 631
• Species: Rattus norvegicus
• Alignment Length: 620
• Identity: 276/620 - (44%)
• Similarity: 378/620 - (60%)
• Gaps: 51/620 - (8%)

  Fly     8 SKSKTP-TPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGI 71
            |..|:| |..:::.:....:||.||.|:||:|||.|..|.|.||||||||||||||||||:||.|
  Rat    31 SPGKSPGTRPEDEADGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFI 95

  Fly    72 MLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFF 136
            .|...|:|:|::|:.:||:..:|.||||.::.|||.|||||.::|...::.||.||:||:..:.|
  Rat    96 FLFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLF 160

  Fly   137 ASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSA 201
            .||...|||..||:.||||.|.                       ..:|..||::.    :..||
  Rat   161 QSFQKDLPWAHCNHSWNTPQCM-----------------------EDTLRRNESHW----VSLSA 198

  Fly   202 VGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVW 266
            .    .|.|...|::.|.:|.|  |.||...|::|||:|||||:|:|:|:|.:|||:.::||||:
  Rat   199 A----NFTSPVIEFWERNVLSL--SSGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVY 257

  Fly   267 FTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAY 331
            |||.||:|:||:||:|||||||:..||::||.||.|.:...:||:||.||:|||.....|.:.:.
  Rat   258 FTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPNISRLEDPQVWIDAGTQIFFSYAICLGAMTSL 322

  Fly   332 ASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAA 396
            .|||||..|.|:|.:|...:||.|||::||.|||:||:||...||.|.|||..||||.|:.||.|
  Rat   323 GSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKA 387

  Fly   397 IATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKR---NRELFVAGLFSLYFVV 458
            :..||..|||:::||:|||.|||||.|...|..||:|.|.:|...|   .||:|:|.:.|:.:::
  Rat   388 VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAIVCSISYLL 452

  Fly   459 GLASCTQGGFYFFHLLDRYAA-GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVC 522
            ||...|:||.|.|.|.|.||| |..:|...|||...::||||.:...:.|.||||:.||.:.:..
  Rat   453 GLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYS 517

  Fly   523 WRFVAPIFLLFITVYGLIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSL 586
            |..:.|...:...::.|:.|.||||.. |.||.||..|||.:|.||:|.||.|.:..|..|.|.|
  Rat   518 WAVITPALCVGCFIFSLVKYVPLTYNKVYRYPDWAIGLGWGLALSSMVCIPLVIVILLCRTEGPL 582

  Fly   587 RQRFTILTTP-----WRDQQ-------SMAMVLNG 609
            |.|...|.||     |..::       |.|.::||
  Rat   583 RVRIKYLITPREPNRWAVEREGATPFHSRATLMNG 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	267/579 (46%)
Slc6a6	XP_008761345.1	SLC5-6-like_sbd	51..592	CDD:444915	265/573 (46%)