Protein Alignment DAT and Slc6a18

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_058859.2
• Gene: Slc6a18 / 29323
• RGDID: 69352
• Length: 615
• Species: Rattus norvegicus
• Alignment Length: 653
• Identity: 226/653 - (34%)
• Similarity: 321/653 - (49%)
• Gaps: 126/653 - (19%)

  Fly    23 ISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELAL 87
            |.|||..|..|:.:|||.|||||.|.|:|||||||:.:||||||:||.|.||..||||||:|||:
  Rat    13 IEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCHTHGGGAFLIPYFIALVFEGIPLFYIELAI 77

  Fly    88 GQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIW 152
            ||..|:|:|..|..:.|...|:|.....::|.|..|||.|:.|.|.||..||.:.|||::|
  Rat    78 GQRLRRGSIGVWKTISPYLGGVGLGCFSVSFLVSLYYNTILLWVLWFFLNSFQHPLPWSTC---- 138

  Fly   153 NTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFN 217
                                                       .||.:..|.|:..||:.:..:.
  Rat   139 -------------------------------------------PLDLNRTGFVQECQSSGTVSYF 160

  Fly   218 RYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIR 282
            .|...||.:..|.:.|.|:|.:.|||:..:...|..:.:||.::|||::|||||||.||.|.|||
  Rat   161 WYRQTLNITSDISNTGTIQWKLFLCLVACWTTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIR 225

  Fly   283 GLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALL 347
            ||||||:..|:.|..|||...:....||:|||||:||||...||..:|:||||:..||..|||:.
  Rat   226 GLTLPGATEGLTYLFTPNMKILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNQPRNNCEKDAVT 290

  Fly   348 TSFINSATSFIAGFVIFSVLG---------------------------------------YMAHT 373
            .:.:||.||..|...|||::|                                       |:..|
  Rat   291 IALVNSMTSLYASITIFSIMGFKASNDYGRCLDRNILSLINEFDFPELSISRDEYPSVLMYLNAT 355

  Fly   374 LGVRIE-------------DVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGG 425
            ...|:.             |.:..||||.|:|:..|:..||.::.|:::||.||.||||.|.||.
  Rat   356 QPERVARLPLKTCHLEDFLDKSASGPGLAFIVFTEAVLHMPGASVWSVLFFGMLFTLGLSSMFGN 420

  Fly   426 SEAIITALSDE--FPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVF 488
            .|.:||.|.|.  .|| ...:|.....:..:.|:..:....|.|.|:..:.|.:||..::::..|
  Rat   421 MEGVITPLFDMGILPK-GVPKETMTGVVCFICFLSAICFTLQSGSYWLEIFDSFAASLNLIIFAF 484

  Fly   489 FEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFL--LFITVYGLIGYEPLTY---- 547
            .|.:.|..:||..||.:||..|.|..|..||||.||.|:|:.|  :|::...|:.....:|
  Rat   485 MEVVGVIHVYGIKRFCDDIEWMTGRRPSLYWQVTWRVVSPMLLFGIFLSYIVLLAQSSPSYKAWN 549

  Fly   548 ---------ADYVYPSWANALGWCIAGSSV--VMIPAVAIFKLLSTPGSLRQRF--TILTTPWRD 599
                     .:.:||.|....  |:..|.:  :.:|.:|:.:||.   ..|||:  |.|.:..:.
  Rat   550 PQYEHFPSREEKLYPGWVQVT--CVLLSFLPSLWVPGIALAQLLF---QYRQRWKNTHLESALKP 609

  Fly   600 QQS 602
            |:|
  Rat   610 QES 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	221/642 (34%)
Slc6a18	NP_058859.2	SLC6sbd_B0AT3	16..591	CDD:212086	215/624 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810