Protein Alignment DAT and Slc6a16

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_038949993.1
• Gene: Slc6a16 / 292902
• RGDID: 1561338
• Length: 850
• Species: Rattus norvegicus
• Alignment Length: 705
• Identity: 185/705 - (26%)
• Similarity: 285/705 - (40%)
• Gaps: 163/705 - (23%)

  Fly     7 ISKSKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGI 71
            |..:||    ..:|:::......||.|.:::|:::|:.|..:.:.||.......|..:|.:.|.:
  Rat   216 IELNKT----SKENSNVFPPWLLWSSKAEYILALMGYLVMPSGLLRFVTCWVHKGSWSFFIAYLL 276

  Fly    72 MLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFF 136
            ||...||||.::|:|:||..::.:|..|..|.|.|.|:||::|::....:.|.||..:|.|.:..
  Rat   277 MLFGLGIPLLFLEMAVGQRAQQSSIDLWKTLSPWFGGLGYSMVMVCLITNTYLNVFNSWILFYMS 341

  Fly   137 ASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSA 201
            ..|...:||..|                    |:..|.||......|:..|.
  Rat   342 HIFHFVVPWDRC--------------------PLQKNSSDFDPECEQATSYT------------- 373

  Fly   202 VGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVY-LICYFSLWKGISTSGKVV 265
                         || .|...|..|:.|.|.|...:::|:.|.:.: |||.|.: .||.:.|||:
  Rat   374 -------------YF-WYRQTLKASDSIEDGGQPSFNLAMFLFLAWCLICVFMV-NGIKSLGKVL 423

  Fly   266 WFTALFPYAVLLILLIRGLTL-PGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLL 329
            ......||.:::..|:|.|:: .|...|:.|.|....:.|....:|..|..||.|.:|.|||.::
  Rat   424 CVLLQVPYFIIICFLVRTLSMGNGIGYGLNYLLILEVARISDLTMWCQAGIQVLFDIGLGFGPVI 488

  Fly   330 AYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMA-----H-------------TLGV 376
            :.:|:....||..|||.|.......|..|......|:||:.|     |             ..|:
  Rat   489 SLSSHMSDFNNCLKDAFLMGLFKIVTLLITTPFFLSILGFWATITTHHCCKKNTNKLLMLIAQGI 553

  Fly   377 -----------------------------------------------RIEDVATEGPGLVFVVYP 394
                                                           ||||    .|..:|:::.
  Rat   554 LPPEVEPPDLNDDPISIYNSWLNSLPPPLRSAVLSMVPECNIQKQFMRIED----SPRFLFLIFT 614

  Fly   395 AAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVG 459
            ..|:.:|.|.||.::||:.||.|||.::.......|..|.|.||..:|...|...|:....|:.|
  Rat   615 EVISLLPGSAFWTVLFFLALLGLGLCTNLMYMLGNILTLQDTFPFCRRQPRLLTVGVSMTTFLCG 679

  Fly   460 LASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFP--PGRYWQVC 522
            |......|.|:|.||..|.....|:..:..|.:||:|.||..||..|:..::..|  ||..|  .
  Rat   680 LIFIQPSGIYYFSLLSEYWVAVPIITIILCETLAVAWAYGAKRFLADMMALLSRPIFPGCSW--L 742

  Fly   523 WRFVAPI----FLLFITVYGLIGYEPLTYADY----------VYPSWANALGWCIAG-SSVVMIP 572
            ||:|:|:    .||||.:|.:.|  ||.|..:          .:|.|:..|   ||| |:||::|
  Rat   743 WRYVSPVVLLGLLLFICIYLVQG--PLVYMAWDSSTSKEVVRYFPMWSLML---IAGLSAVVLMP 802

  Fly   573 AVAIFKLLSTPGSLRQRFTILTTPWRDQQSMAMVLNGVTTEVTVVRLTDTETAKE 627
            ..|.|......|          .|:|...|..:.|.....      ||..|.:|:
  Rat   803 IPAYFAYCLNLG----------IPFRSAPSCKLPLGSGQL------LTTKEASKD 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	173/653 (26%)
Slc6a16	XP_038949993.1	SLC6sbd_NTT5	232..802	CDD:271392	169/628 (27%)