Protein Alignment DAT and SLC6A16

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_011525161.2
• Gene: SLC6A16 / 28968
• HGNCID: 13622
• Length: 781
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 168/631 - (26%)
• Similarity: 257/631 - (40%)
• Gaps: 172/631 - (27%)

  Fly    27 RETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHN 91
            |..||.|.:::|:.:||::..:.:|||.||...:||.:|...|..||.:.|:||.::|:|.||..
Human   185 RPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSM 249

  Fly    92 RKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPN 156
            |:|.:..|..:.|...|:||:..::.|.:..|:||:.:|.:.:...||...:||..|
Human   250 RQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKC-------- 306

  Fly   157 CRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYIL 221
                        |:.                    ||.|..|.      |..::..|.|| .|..
Human   307 ------------PLT--------------------MNSSGFDP------ECERTTPSIYF-WYQQ 332

  Fly   222 ELNRSEGIHDLGAIKWDMAL------CLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILL 280
            .|..|:.|.|.|:..:.:.|      ||:..::|      .|:.::||:
Human   333 ALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMI------NGLKSTGKI---------------- 375

  Fly   281 IRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDA 345
                                 |.:|...||..|..||..:.|.|.|.:.:.|||....||...||
Human   376 ---------------------SDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDA 419

  Fly   346 LLTSFINSATSFIAGFVIFSVLGYMA--------------------------------------- 371
            .|.|.||..|..:.....|.|||:.|
Human   420 FLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPT 484

  Fly   372 ------------HTLGVRIEDV-----------ATEGPGLVFVVYPAAIATMPASTFWALIFFMM 413
                        |...:.:.:|           |:|||...|:.:..|::.:|.|.||:.|||:|
Human   485 SIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLM 549

  Fly   414 LLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYA 478
            ||.:||.|:.|..:.|||.|.|.|...:::.:|.:.|:|.|.||.||......|.||..||..|.
Human   550 LLAMGLSSAIGIMQGIITPLQDTFSFFRKHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYW 614

  Fly   479 AGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLL--FITVYGLIG 541
            ..:.|:|.|.||.:||||.||..||..|:..::|.|....:...|..:.|:.||  |:|:...:.
Human   615 IVFPIIVVVVFETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLC 679

  Fly   542 YEPLTYADY----------VYPSWANALGWCIAGSSVVMIPAVAIF 577
            .:|:||..:          .||.||..|  .|...::|::|..|.|
Human   680 MKPITYMSWDSSTSKEVLRPYPPWALLL--MITLFAIVILPIPAYF 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	168/631 (27%)
SLC6A16	XP_011525161.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820