Protein Alignment DAT and Slc6a15

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_758824.1
• Gene: Slc6a15 / 282712
• RGDID: 628664
• Length: 729
• Species: Rattus norvegicus
• Alignment Length: 636
• Identity: 217/636 - (34%)
• Similarity: 330/636 - (51%)
• Gaps: 124/636 - (19%)

  Fly    19 DNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYM 83
            |.:.:.|||..|:.|:.::|:.:||:|.|.|||||||||.||||||:|:||.|:|:|.|||||::
  Rat    53 DGSEVDDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLLVIGIPLFFL 117

  Fly    84 ELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSC 148
            ||::||..|:|:|..|..:.|...|||:|..::.::|..||||||.|:|.:|..||...|||..|
  Rat   118 ELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWTLFYFSQSFQQPLPWDQC 182

  Fly   149 NNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAAS 213
                                |::.|.|             .||:......:||..:
  Rat   183 --------------------PLVKNAS-------------HTYIEPECEKSSATTY--------- 205

  Fly   214 EYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLI 278
             |:.|..|.:  |..|.:.|.:.|.|..|||..:::...::.|||.:|||:::|::||||.||:.
  Rat   206 -YWYREALAI--SSSISESGGLNWKMTGCLLAAWVMVCLAMIKGIQSSGKIMYFSSLFPYVVLIC 267

  Fly   279 LLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYK 343
            .|||.|.|.||..||::..||....:.:.:||.:|||||||:||.|||.::|::||||..||.:.
  Rat   268 FLIRSLLLNGSIDGIRHMFTPKLEMMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHF 332

  Fly   344 DALLTSFINSATSFIAGFVIFSVLGYMA------------------------------------- 371
            ||:|.||||..||.:|..|:|:|||:.|
  Rat   333 DAVLVSFINFFTSVLATLVVFAVLGFKANIVNEKCISQNSEMILKLLKTGNVSWDVIPRHINLSA 397

  Fly   372 ------------------------HTLGVRIED---VATEGPGLVFVVYPAAIATMPASTFWALI 409
                                    |....:|||   .|.:|.||.|:.:..|:...|||.||:::
  Rat   398 VTAEDYHVVYDIIQKVKEEEFAVLHLKACQIEDELNKAVQGTGLAFIAFTEAMTHFPASPFWSVM 462

  Fly   410 FFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLL 474
            ||:||:.|||.|.||..|.|||.:.|.|   |..:|:.......|.|.:||....:.|.||..:.
  Rat   463 FFLMLINLGLGSMFGTIEGIITPVVDTF---KVRKEILTVICCLLAFCIGLMFVQRSGNYFVTMF 524

  Fly   475 DRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGL 539
            |.|:|...:|:.|..|.||||::||.::|.||:.||:||.|.:|:...|::::|:.|:.:.:..:
  Rat   525 DDYSATLPLLIVVILENIAVSFVYGIDKFLEDLTDMLGFAPSKYYYYMWKYISPLMLVTLLIASI 589

  Fly   540 I--GYEPLTYADYV----------YPSWANALGWCIAGSSVVMIPAVAIFK 578
            :  |..|..|..::          ||.|...:.:.:...:::.:|.|.:.:
  Rat   590 VNMGLSPPGYNAWIKEKASEEFLSYPMWGMVVCFSLMVLAILPVPVVFVIR 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	214/628 (34%)
Slc6a15	NP_758824.1	SLC6sbd_SBAT1	61..640	CDD:212091	214/626 (34%)